VALIDATED RP-HPLC METHOD FOR ESTIMATION OF GRANISETRON IN API AND DOSAGE FORM
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Granisetron, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 250mm, 5µm) column using a mixture of Acetonitrile and Water (50:50% v/v) as the mobile phase at a flow rate of 0.8ml/min, the detection was carried out at 285nm. The retention time of the Granisetron was 3.0 ±0.02min. The method produce linear responses in the concentration range of 20-100µg/ml of Granisetron. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Granisetron, RP-HPLC, validation.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP277757
- DOI -
- Views 263
- Downloads 0
ANTECEDENTS OF DENGUE VIRUS DURING THE CLINICAL INVESTIGATIONS IN FAISALABAD
Background: Dengue is the most important viral mutagenic disease in public health, caused by one of the four serotypes (DEN-1, 2, 3 and 4) of the dengue virus, a positive chain RNA virus of the Flaviviridae family, which...
THE BORDERING AREAS (NINE AREAS OF PANJGUR DISTRICT) ISSUE OF PAKISTAN ABOUT HUMAN MALARIA PREVALENCE: A CROSS-SECTIONAL RESEARCH OF MALARIA PARASITES IDENTIFICATION IN BLOOD SLIDES
Objective: The objective of research was the malaria infection prevalence identification in the population of Southern Western Pakistan (Panjgur). Methods: Our research was by design cross-sectional and it identified the...
IN VITRO ANALYSIS OF SECONDARY METABOLITES FROM MUNTINGIA CALABURA CHLOROFORM EXTRACT.
In recent times, focus on medicinal plants research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. For many...
ROLE OF HEALTH EDUCATION AND ENVIRONMENTAL MEDICAL ISSUES IN ELECTORAL PROCESS IN PAKISTAN
Objective: Research was held for the evaluation of wheatear health education and other environmental medical and social issues influence the electoral process in Pakistan. Study design: Exploratory quantitative and case...
FORMULATION AND EVALUATION OF ANTIOXIDANT CREAM FROM METHANOL LEAVES EXTRACT OF POLYGONUM MINUS
Oxidative stress is considered as one of the vital factor that causes serious ailments to humans. The free radicals speeds up the aging process and thus, the need of antioxidants gains importance as it will help to prote...