VALIDATED RP-HPLC METHOD FOR ESTIMATION OF GRANISETRON IN API AND DOSAGE FORM
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Granisetron, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 250mm, 5µm) column using a mixture of Acetonitrile and Water (50:50% v/v) as the mobile phase at a flow rate of 0.8ml/min, the detection was carried out at 285nm. The retention time of the Granisetron was 3.0 ±0.02min. The method produce linear responses in the concentration range of 20-100µg/ml of Granisetron. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Granisetron, RP-HPLC, validation.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP277757
- DOI -
- Views 286
- Downloads 0
NEURO AND ANALGESIC ACTIVITIES OF OLIVE LEAF METHANOLIC CRUDE EXTRACT
Genus Olea (Oleaceae) are prominent for its therapeutic value and are comprised in British and Indian pharmacopeias. In Pakistan Olea europaea leaves widely spread in Baluchistan province, NWFP, Punjab and in northerly a...
A NEW METHOD DEVELOPMENT AND VALIDATION OF AXITINIB BULK AND PHARMACEUTICAL DOSAGE FORM BY USINGUV-VISIBLE SPECTROSCOPY AS PER ICH GUIDELINES
The objective of the present work was to develop a simple, efficient and reproducible spectrophotometric method for the quantitative estimation of Axitinib drug in its active pharmaceutical ingredient (API) form. The dev...
A STUDY OF PERVASIVENESS OF HEPATOTOXICITY AND OTHER SIDE EFFECTS OF ANTI-TUBERCULOSIS DRUGS ON PULMONARY KOCH PATIENTS.
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. About 10% of latent infections progress to active disease which, if left untreated, kills about half of those infected. In im...
EFFECTS OF THROMOBOLYTIC THERAPY IN THE PATIENTS OF MYOCARDIAL INFRACTION
Objective: To minimize the response reperfusion time through the administration of drugs – Thrombolytic Therapy. Methods: The study was conducted from January 2017 to October 2017 at Allied Hospital Faisalabad. Initially...
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-CYCLIC AMINE BENZOTHIAZOLE DERIVATIVES
The synthesis of a new series of 2-(cyclic amine)-1, 3-benzothiazole derivatives were synthesized in satisfactory yield and evaluated for their anti-microbial activities. 2-(cyclic amine)-1, 3-benzothiazoles were synthes...