Validated UV Spectrophotometric Methods for the Estimation of Aceclofenac in Bulk and Pharmaceutical Formulation
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 6
Abstract
Aceclofenac, 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acidis a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Simple, rapid, accurate, specific and highly sensitive UV spectroscopic methods were developed and validated for the estimation of Aceclofenac in bulk and pharmaceutical dosage form. The absorption maxima was found to be 274.65nm for the method A(Zero order), 259nm for method B(first order derivative) and for method C(Area under curve) was measured from 269-279nm. The solvent used was methanol: water(40:60) for the preparation of stock solution and distilled water was used for the further dilutions. The methods were found to be linear in the range of 5-30μg/ml and the correlation coefficient values were found to be 0.9994, 0.9991, 0.9995 respectively. The developed methods were validated in terms of linearity, accuracy, precision in accordance with the ICH guidelines. The proposed methods can be used for the estimation of Aceclofenac in bulk and Pharmaceutical dosage forms. Keywords: Aceclofenac, Area under curve, First order derivative spectroscopy, Validation.
Authors and Affiliations
Srujani. Ch, Sravanthi. B, Madhuri. D
Keywords
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