VANISHING WHITE MATTER DISEASE: A CASE REPORT
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 12
Abstract
Vanishing white matter disease (VWM) is one of the most prevalent inherited childhood Leucoencephalopathies. We report MR imaging features of vanishing white matter disease in a 4-year-old boy, who manifested with seizures, aphasia, spastic quadriparesis and myoclonic jerks. MRI of brain showed diffuse white matter signal changes of CSF intensity in all the sequences. MR spectroscopy of white matter showed severe decrease in NAA, choline and creatine and presence of lactate peak. Additional notable findings were diffuse extensive brain stem and thalamic atrophy. The clinico-radiological correlation was consistent with the diagnosis of vanishing white matter disease. Reporting of such cases may widen the spectra of these disorders.
Authors and Affiliations
Sindu P. Gowdar, Naveen S. Maralihalli, Pramod Setty J, Rajesh Venunath, Mithila P. V.
Keywords
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- EP ID EP226726
- DOI 10.18410/jebmh/2015/265
- Views 74
- Downloads 0
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