VARIATION IN THE YAK CALPASTATIN GENE (CAST)
Journal Title: International Journal of Genetics - Year 2012, Vol 4, Issue 1
Abstract
Calpastatin (CAST) is a specific inhibitor of calpain (calcium-dependent cysteine protease). This study investigated the potential for variation in yak (Bos grennies) CAST. PCR-SSCP analysis of exon 6 of yak CAST revealed three unique patterns (named A-C). Sequencing of the amplicons revealed two nucleotide substitutions. One substitution (c.398G/C) would nominally change the amino acid sequence (p.S133T) of yak calpastatin. The variant sequence A which carried c.398C was the most common in the yaks tested (95.1%). This is the first report that found yak CAST is variable, and as in pigs, sheep and cattle, this variation may affect animal production traits.
Authors and Affiliations
J. G. H. HICKFORD, G. YANG, H. ZHOU, J. HU, Y. LUO
Keywords
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- DOI 10.9735/0975-2862.4.1.72-73
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