Variations in the Number of Circulating Tumor Cells During the Surgical Sequence for Locally Advanced Rectal Cancer
Journal Title: JURNALUL DE CHIRURGIE [JOURNAL of SURGERY] - Year 2017, Vol 13, Issue 1
Abstract
Aim: This study aims to assess the variation of the levels of circulating tumor cells during surgical manipulation, by in vivo evaluation at three key points during treatment. Materials and methods: This was a pilot study with 20 included patients with mid and low locally advanced rectal cancer, with neoadjuvant treatment. The device used to evaluate the number of circulating tumor cells in the bloodstream of the patients was the “Detektor Cancer” GILUPI Cell Collector®. The tests were performed at 8 weeks after the end of the neoadjuvant treatment, at three key moments: in the preoperative period, during surgery - after the surgical dissection and at 7 days postoperatively. Results: There was an increase in the number of circulating tumor cells after the surgical sequence, but no statistical significance could be achieved due to the small number of patients included in the study. Conclusion: The circulating tumor cell number is a useful biomarker for the prognosis of the patients with colorectal cancer, demonstrated through several studies. However, there is need for standardization in this field of research. Our study, although with visible differences between the preoperative, intraoperative and postoperative values, showed no statistical significance.
Authors and Affiliations
Dragos Viorel Scripcariu, Gabriel Dimofte, Dan Ferariu
Keywords
Related Articles
- EP ID EP288485
- DOI 10.7438/1584-9341-13-1-6
- Views 112
- Downloads 0
A Rare and Interesting Case of Mediastinal Fibromatosis
Mediastinal fibromatosis is a rare entity affecting individuals of all age groups, and is extremely rare in children. Fibromatosis can occur anywhere in the body; most commonly in the superficial soft tissues, extremitie...
Kummell's Disease, Case Report of a Delayed Onset Paraparesis and Literature Review
Introduction: Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterized by the gradual development in time of a vertebral body collapse...
The Number of 7 Patient’s Clinical Analysis of Duodenal Neuroendocrine Neoplasms
Aim: The aim of this study was to report and analyze outcomes associated 7 patient’s in-hospital evaluation and investigate of the cliniopathological features diagnosis and treatment of duodenal neuroendocrine neoplasms....
Rapidly Progressive Osteolysis of the Femoral Head Following An Acetabular Fracture - Case Report
Posttraumatic osteolysis is a rare complication of fractures. We present a case of massive, rapidly progressive osteolysis of the femoral head following a fracture of the acetabulum. A 45 years old male patient suffered...
Presepsin: Early Biomarker in Diagnosis of Sepsis in Emergency Department
Objective: Sepsis is a common syndrome with devastating implications for health care systems worldwide. Biomarkers may play an important role in highlighting the presence, absence or severity of sepsis. Materials and me...