Variations in the Number of Circulating Tumor Cells During the Surgical Sequence for Locally Advanced Rectal Cancer
Journal Title: JURNALUL DE CHIRURGIE [JOURNAL of SURGERY] - Year 2017, Vol 13, Issue 1
Abstract
Aim: This study aims to assess the variation of the levels of circulating tumor cells during surgical manipulation, by in vivo evaluation at three key points during treatment. Materials and methods: This was a pilot study with 20 included patients with mid and low locally advanced rectal cancer, with neoadjuvant treatment. The device used to evaluate the number of circulating tumor cells in the bloodstream of the patients was the “Detektor Cancer” GILUPI Cell Collector®. The tests were performed at 8 weeks after the end of the neoadjuvant treatment, at three key moments: in the preoperative period, during surgery - after the surgical dissection and at 7 days postoperatively. Results: There was an increase in the number of circulating tumor cells after the surgical sequence, but no statistical significance could be achieved due to the small number of patients included in the study. Conclusion: The circulating tumor cell number is a useful biomarker for the prognosis of the patients with colorectal cancer, demonstrated through several studies. However, there is need for standardization in this field of research. Our study, although with visible differences between the preoperative, intraoperative and postoperative values, showed no statistical significance.
Authors and Affiliations
Dragos Viorel Scripcariu, Gabriel Dimofte, Dan Ferariu
Keywords
Related Articles
- EP ID EP288485
- DOI 10.7438/1584-9341-13-1-6
- Views 100
- Downloads 0
Presepsin: Early Biomarker in Diagnosis of Sepsis in Emergency Department
Objective: Sepsis is a common syndrome with devastating implications for health care systems worldwide. Biomarkers may play an important role in highlighting the presence, absence or severity of sepsis. Materials and me...
Fistulas after Low Anterior Resection with TME
Despite advances in modern anastomotic techniques for colorectal surgery, anastomotic fistulas are still considered a dreaded complication, with a reported rate varying from 2 to 25%. Although fistulas can appear after a...
Parotidectomy in a 54 Years Old Patient: Case Report
Parotid gland tumors account for 80% of all salivary gland neoplasms, 20% of these are malignant, but in daily clinical practice most parotid masses are operated on before obtaining the final histological diagnosis. This...
Kummell's Disease, Case Report of a Delayed Onset Paraparesis and Literature Review
Introduction: Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterized by the gradual development in time of a vertebral body collapse...
Multivisceral Resections in Advanced Gastric Cancer-Case Report
Background: Gastric cancer is an important cause of death in worldwide, despite the progress achieved through screening programs. Multivisceral resections are dictated by R0 resection gold, but also by the histopathologi...