Varicella zoster virus related deaths and hospitalizations before the introduction of universal vaccination with the tetraviral vaccine
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 4
Abstract
Objective To characterize varicella zoster virus-related deaths and hospitalizations in Brazil before universal vaccination with the tetravalent (measles, mumps, rubella, and varicella) vaccine, attempting to collect baseline data on varicella morbidity and mortality in order to evaluate the impact of the varicella vaccination program. Methods Varicella-associated mortality data were evaluated between 1996 and 2011 and varicella zoster virus-associated hospitalizations between 1998 and 2013. Data were gathered from the Informatics Department of the Unified Health System, considering the International Classification of Diseases, 10th Revision, code B01. All age groups were assessed. Varicella-specific mortality rates were calculated and seasonality of varicella-zoster virus-associated hospitalizations was described. Results There were 2334 varicella deaths between 1996 and 2011, 19.3% in infants aged less than 1 year and 36% in children from 1 to 4 years. In infants under 1 year, varicella mortality rates reached 3.2/100,000/year. In children aged 1–4 years, varicella mortality rates reach 1.64/100,000/year. Average annual mortality rates for varicella in Brazil are 0.88/100,000 in infants under 1 year and 0.40/100,000 in children aged 1–4 years. The total number of hospitalizations associated with varicella zoster virus was 62,246 from 2008 to 2013. Varicella-associated hospitalizations have a seasonal distribution in children, peaking in November. In the elderly, monthly averages of herpes zoster-associated hospitalizations present no significant seasonal variation. Conclusions Varicella is associated, in the pre-vaccine period, to significant morbidity and mortality in Brazil. The universal vaccination program is expected to decrease the disease burden from varicella.
Authors and Affiliations
Filipe Carvalho-Costa
Keywords
Related Articles
- EP ID EP513681
- DOI 10.1016/j.jped.2015.10.003
- Views 83
- Downloads 0
Accuracy of low dose CT in the diagnosis of appendicitis in childhood and comparison with USG and standard dose CT
Objectives Computed tomography should be performed after careful consideration due to radiation hazard, which is why interest in low dose CT has increased recently in acute appendicitis. Previous studies have been perfor...
Repercussions of inborn errors of immunity on growth
Objectives This study aimed to review the literature on the repercussions of the different inborn errors of immunity on growth, drawing attention to the diagnosis of this group of diseases in patients with growth disorde...
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives
Objective The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods This was a quasi-experimental study. The adolescents...
Effectiveness of a measure program to prevent admission hypothermia in very low-birth weight preterm infants
Objective To evaluate the effectiveness of a thermoregulation bundle for preventing admission hypothermia in very low-birth weight preterm infants. Methods Interventional study with retrospective evaluation of data unde...
Birth weight and its association with blood pressure and nutritional status in adolescents
Objective The management of children with low birth weight is not the same in countries with different resources. The authors assessed the association of birth weight with blood pressure and nutritional status in a repre...