ВАСКУЛОЕНДОТЕЛІАЛЬНИЙ ФАКТОР РОСТУ А ТА ПОЛІМОРФІЗМ G634C ГЕНА ВЕФР-A У ХВОРИХ ІНФАРКТОМ МІОКАРДА В ГОСТРИЙ ТА ВІДДАЛЕНИЙ ПЕРІОДИ
Journal Title: World Science - Year 2018, Vol 2, Issue 8
Abstract
Vascular endothelial growth factor A (VEGF-A) promotes the survival of endothelial cells during acute myocardial infarction, accelerates the development of collateral blood supply to ischemic myocardium, and affects the size diminishing of the necrotic lesion area. The synthesis of the VEGF-A in response to standard stimuli is different between people that is genetically determined. The aim was to study the association of polymorphous variants of the VEGF-A gene (G634C) with the dynamics of structural and functional parameters of left ventricle in patients with acute ST elevation myocardial infarction (STEMI) during a 6-month period. A significantly higher VEGF-A concentration was determined in the carriers of the GG genotype compared to the GC genotype (p = 0.047) in the acute period. It has been established that the genotype GC in patients with acute myocardial infarction ST-elevation (STEMI) is associated with more pronounced changes in the left ventricular geometry during the acute period. The GC genotype is associated with a better blood pressure control and a decrease in the left ventricle mass after 6 months’ observation.
Authors and Affiliations
М. П. Копиця, І. М. Кутя, Ю. В. Родіонова
Keywords
Related Articles
- EP ID EP545450
- DOI 10.31435/rsglobal_ws/30082018/6061
- Views 92
- Downloads 0
НЕФТЕГАЗОДОБЫВАЮЩАЯ ОТРАСЛЬ - ОХРАНА ОКРУЖАЮЩЕЙ СРЕДЫ
.
СОСТОЯНИЕ МОЗГОВОГО КРОВООБРАЩЕНИЯ У ПАЦИЕНТОВ С ДИАБЕТИЧЕСКОЙ ЭНЦЕФАЛОПАТИЕЙ ПРИ САХАРНОМ ДИАБЕТЕ 2 ТИПА
Thirty patients with diabetic encephalopathy underwent Doppler transcranial sonography. Investigation was performed taking into account types of diabetic encephalography, durability of diabetes mellitus and stage of co...
MEANS TO DETECT HARMFUL FOR CHILDREN CONTENT AND MEASURES TO PREVENT ITS SPREAD
In the article the issue of involving children through popular social networks in the so-called death games is discussed. We consider the main visual signs, by which it is possible to recognize the accounts of children w...
ОСОБЛИВОСТІ ГОРМОНАЛЬНОГО СТАТУСУ ТА ЛІПІДНОГО ОБМІНУ У ЧОЛОВІКІВ З ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ
The study of aging has an important place in modern medicine, as it is associated with an increase in life expectancy and, consequently, the number of aging people. The criterion of age-related changes of the population...
МЕТОДИКА ВИХОВАННЯ ОСОБИСТОСТІ МАЙБУТНЬОГО ВЧИТЕЛЯ В ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОМУ СЕРЕДОВИЩІ ВИЩОГО НАВЧАЛЬНОГО ЗАКЛАДУ
Education – the main category of pedagogical science. A person is brought up continuously, his personality is formed throughout his life under the influence of numerous factors, objective and subjective, natural and soci...