Veterinary control of the residual amounts of tylosin and doxycycline in broiler chickens'' products
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2017, Vol 30, Issue
Abstract
Introduction. The problem of production of qualitative and safe poultry products in Ukraine is solved by using a large number of veterinary preparations that can accumulate in poultry and cause adverse effects in human bodies, such as allergic reactions, disbacteriosis, etc. These drugsinclude macrolide antibiotics - farmazin and tylocyclinvet - they are widely used in poultry production. The goal of the work is to define residual quantities of tylosin tartrate and doxycycline hyclate in muscles and internal organs of broiler chickens, which have been treated with formazine and tylocyclinvet by arbitration method - liquid chromatography. Materials and methods. We used four groups of one day old broiler chickens of Cobb 500 cross - two control and two experimental (12 broiler chickens in each). Chicken of the first experimental group were given to drink farmazin drug containing the active substance (AS) of tylosin tartrate 500 mg/g, and of the second group - tylocyclinvet containing AS tylosin tartrate and doxycycline hyclate in dose 100 mg/g in powder form. Antibiotics were given to drink to broiler chickens with preventative purpose at a dose of 1 g per 1 dm3 of water for the first 3 days of life, then in the 28-29 and 38-42 days of experiment. After the antibiotics giving, group with 6 broiler chickens of each group were slaughtered at the beginning of elimination (in 3 hours) and at the end of the withdrawal period (in 5-8 days) respectively, after the last farmazin and tylocyclinvet usage. Results of research and discussion. These data suggested that tylosin is rapidly absorbed from the gastrointestinal tract into the blood and penetrates practically in all organs and tissues of the organism. The highest concentrations of tylosin tartrate were found in the broadest muscles of the back, the chest muscles, the liver at the beginning of the carention period, and after the elimination period the residues amount of tylosin was found in the broadest muscles of the back, the middle part of the iliotibial tract and the caudal iliac, and the acetabular muscle as well, which exceeded relative maximum residue levels (RMRL). The obtained results are explained by an anatomical structure, physiological growth and development of poultry, because the most functional load falls on the mentioned above muscle groups.We found that after 3 hours after the last tylocyclinvet giving doxycycline was not detected. After the elimination period there were found some minimal residual amounts of doxycycline in all groups of muscles and internal organs, these amounts did not exceed RMRL, except of the gizzard stomach - 105.8±34.3 mg/kg, which exceeded MRL. Conclusions and prospects for further research. For the purpose of objective control of the tylosin residues in broiler chickens' products it is important to investigate the broadest muscle of the back, the middle part of the iliotibial tract, the caudal iliac and the acetabular muscle of poultry, and gizzard stomach for doxycycline presence.
Authors and Affiliations
Inna Zabarna, Natalia Golovko
Keywords
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- EP ID EP267293
- DOI 10.31073/vet_biotech30-09
- Views 177
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