Vitamin D and rheumatoid arthritis
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 3
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic pain and impairment of joints as well as progressive disability. RA affects 0,5-1% of adults in developed countries. The disease is three times more frequent in women than in men. Although the pathophysiology of RA is more and more clear the etiology of the disease remains unknown.<br>The awareness of a role of vitamin D in the regulation of immune responses was triggered by the discovery of vitamin D receptors in almost all immune cells, including activated T and B lymphocytes, neutrophils, and antigen-presenting cells: macrophages and dendritic cells.<br>Epidemiological evidence indicates that vitamin D deficiency is accompanied by an increase in incidence of autoimmune disease. Significant vitamin D deficiency, more pronounced than in general population, was found in patients with RA. An inverse relationship between serum level of 25-OH vitamin D and early onset polyarthritis, severity of the disease as well as a degree of disability of the patients with RA were reported.<br>Immunomodulating effects of vitamin D in patients with RA are related to a decrease in the number of Th1 and Th17 lymphocytes, to an increase in the number of Th2 and T-reg cells as well as to diminishing the production of proinflammatory cytokines together with increasing the secretion of antyinflammatory cytokines.<br>Many issues referrng the influence of vitamin D and its metabolites on the incidence and severity of RA remains unclear and needs further examinations.
Authors and Affiliations
Agnieszka Jasik, Marek Tałałaj
Keywords
Related Articles
- EP ID EP54411
- DOI -
- Views 95
- Downloads 0
Operacje redukcyjne przerosłych i opadniętych piersi w materiale Kliniki Chirurgii Plastycznej CMKP w Warszawie
Wstęp. Przerost i opadnięcie piersi znacznego stopnia jest leczone chirurgicznie ze wskazań medycznych. Powodem zgłaszania się pacjentek do leczenia były schorzenia kręgosłupa, dolegliwości spowodowane uciskiem ramiączek...
Assessment of efficacy of intravascular ovarian vein occlusion for the treatment of pelvic congestion syndrome
Introduction. Chronic pelvic pain (CPP) is responsible for 20% of gynaecological outpatient visists. Pelvic congestion syndrome (PCS) is a common cause of CPP, which is underlain by the varicose and incompetent veins wit...
Przezskórne leczenie jatrogennych tętniaków rzekomych tętnicy udowej
Wstęp. Badania i zabiegi przeznaczyniowe są powszechnie stosowane w kardiologii i radiologii zabiegowej. Umożliwiają dokładną diagnostykę i wewnątrznaczyniowe leczenie chorób naczyń.Zabiegi przeznaczyniowe zaliczane są d...
Tissue engineered products for pediatric patients
Tissue Engineering, a new field of regenerative medicine, offers products for tissue regeneration obtained by means of cell culture, biomaterials and factors which stimulate tissue growth. Tissue engineered products (TEP...
Non-small-cell lung cancer
Despite the introduction of numerous new options in the treatment of non-small-cell lung cancer in recent years, survival rates of patients remain unsatisfactory. Further progress depends on successful attempts to clearl...