Vitamin D and rheumatoid arthritis

Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 3

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic pain and impairment of joints as well as progressive disability. RA affects 0,5-1% of adults in developed countries. The disease is three times more frequent in women than in men. Although the pathophysiology of RA is more and more clear the etiology of the disease remains unknown.<br>The awareness of a role of vitamin D in the regulation of immune responses was triggered by the discovery of vitamin D receptors in almost all immune cells, including activated T and B lymphocytes, neutrophils, and antigen-presenting cells: macrophages and dendritic cells.<br>Epidemiological evidence indicates that vitamin D deficiency is accompanied by an increase in incidence of autoimmune disease. Significant vitamin D deficiency, more pronounced than in general population, was found in patients with RA. An inverse relationship between serum level of 25-OH vitamin D and early onset polyarthritis, severity of the disease as well as a degree of disability of the patients with RA were reported.<br>Immunomodulating effects of vitamin D in patients with RA are related to a decrease in the number of Th1 and Th17 lymphocytes, to an increase in the number of Th2 and T-reg cells as well as to diminishing the production of proinflammatory cytokines together with increasing the secretion of antyinflammatory cytokines.<br>Many issues referrng the influence of vitamin D and its metabolites on the incidence and severity of RA remains unclear and needs further examinations.

Authors and Affiliations

Agnieszka Jasik, Marek Tałałaj

Keywords

Related Articles

VAP-1 i renalaza u pacjentów po transplantacji narządów unaczynionych

Jedną z metod leczenia schyłkowej niewydolności narządów jest przeszczep narządu pobranego od innej osoby. Wśród pacjentów po przeszczepieniu często obserwuje się dysfunkcję śródbłonka. Jest ona także bardzo powszechna w...

Current therapeutic options in children with hypertrophic cardiomyopathy – own experience

Introduction. The clinical course of hypertrophic cardiomyopathy (HCM) in children is very heterogeneous. In some children, the thickened heart muscle causes progressive heart failure and life-threatening arrhythmias. HC...

New perspectives on the pathogenesis and treatment of hair disorders

In recent years, along with the progress of balding has been on the rise, which is reflected both in the prevalence of the problem and in the persistently low treatment efficacy. The leading causes of diffuse hair loss a...

Choroby reumatyczne u kobiet w ciąży

Choroby reumatyczne często dotyczą ludzi młodych, w tym kobiet w wieku rozrodczym. Problem ciąży w tej grupie nie jest rzadkością. Główne choroby reumatyczne, które spotykamy u kobiet w ciąży to: reumatoidalne zapalenie...

Endoskopowa cholagiopankreatografia wsteczna (ECPW) u dzieci z chorobami trzustki

Endoskopowa cholangiopankreatografia wsteczna (ECPW) jest wartościową metodą diagnostyczno-terapeutyczną w chorobach dróg żółciowych oraz trzustkowych w populacji pediatrycznej. Technika wykonywania ECPW nie jest trudnie...

Download PDF file
  • EP ID EP54411
  • DOI -
  • Views 97
  • Downloads 0

How To Cite

Agnieszka Jasik, Marek Tałałaj (2012). Vitamin D and rheumatoid arthritis. Postępy Nauk Medycznych, 25(3), -. https://europub.co.uk/articles/-A-54411