VITAMIN D DEFICIENCY- A POSSIBLE CONTRIBUTING FACTOR IN THE AETIOPATHOGENESIS OF ORAL LICHEN PLANUS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 66
Abstract
BACKGROUND Lichen planus is a chronic autoimmune disease involving skin and mucous membrane. It is believed to represent an abnormal immune response in which epithelial cells are recognised as foreign, secondary to changes in the antigenicity of the cell surface. Certain epidemiological studies are indicative of significant association between vitamin D deficiency and increased incidence of autoimmune diseases. The aim of the present study is to investigate the role of vitamin D in Oral Lichen planus patients and the relationship between serum vitamin D Levels and different clinical forms of Oral lichen planus. MATERIALS AND METHODS A convenience sample of 20 cases who were previously diagnosed as Oral lichen planus patients as per Modified World Health Organisation diagnostic criteria of OLP and OLL (2003), and enrolled in the Department of Oral Medicine & Radiology, were selected. A group of 20 age and sex matched healthy controls were included. 25-Hydroxyvitamin D [25(OH) D] Levels were measured by ECLIA (Electrochemiluminescence immunoassay) method in patients and control group. RESULTS Statistically Significant Association (P-value<0.05) of serum vitamin D levels was seen in patients with Oral lichen planus. CONCLUSION The results of our study suggest that Vitamin D levels may have an important role in the aetiopathogenesis of the disease or may be one of the contributory factors that determines the progression and prognosis of the disease, and as such it is needed that a study with a larger sample size may be conducted in order to establish the role of vitamin D in the aetiopathogenesis of Oral Lichen planus.
Authors and Affiliations
Mohsin Muzaffar Tak, Altaf Hussain Chalkoo
Keywords
Related Articles
- EP ID EP231898
- DOI 10.14260/Jemds/2017/1033
- Views 112
- Downloads 0
BIOCHEMICAL PROFILE AND VARIOUS TREATMENT MODALITIES OF PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH)
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized condition that may progress to end stage liver disease. Although non-alcoholic steatohepatitis (NASH) was considered relatively uncommon...
LEFT PARADUODENAL HERNIA- A CASE REPORT
PRESENTATION OF CASE During routine abdominal dissection of a 45-year-old male cadaver, upon entering the peritoneal cavity, a left Paraduodenal Hernia (PDH) was observed. The sac contained the first few centimetres of t...
CLINICAL PROFILE OF ACUTE VIRAL HEPATITIS– A AND FACTORS ASSOCIATED WITH BAD OUTCOME
BACKGROUND Hepatitis A is the most common cause of acute viral hepatitis. There has been an increase in the disease burden in many parts of the world, along with more complications and many atypical manifestations. The m...
A COMPARATIVE STUDY OF THREE SUPRAGLOTTIC AIRWAY DEVICES- CLASSIC LMA, PROSEAL LMA AND I-GEL, IN ADULT PATIENTS UNDERGOING ELECTIVE SURGERIES
BACKGROUND Supraglottic airway devices are gaining popularity because of their ease of insertion, simplicity as well as effective ventilation. This study is aimed at comparing the clinical performance of LMA-Classic, LMA...
A COMPARISON OF ACAPELLA AND CHEST PHYSICAL THERAPY IN PATIENTS WITH BRONCHIECTASIS- A PILOT STUDY
BACKGROUND Rehabilitation from bronchiectasis is an easy process, which involves a dedicated multidisciplinary team of professionals and full participation of the patient. Acapella is a hand held device which incorporate...