Vitamin D deficiency in obesity and its relationship to insulin resistance and plasma leptin levels – preliminary study
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 1
Abstract
Introduction. Obesity is a risk factor for vitamin D deficiency and there is some evidence that vitamin D may be involved in the pathogenesis of insulin resistance.Aim. The aim of the study was to evaluate whether vitamin D deficiency is associated with insulin resistance and leptin level in obese subjects.Material and methods. 43 obese (body mass index (BMI) ≥ 35 kg/m2) individuals before bariatric surgery and 16 healthy volunteers with normal body weight were enrolled in this study. In all subjects serum level of glucose, 25-hydroxyvitamin D (25(OH)D), calcium, insulin, leptin, leptin soluble receptor were evaluated, insulin resistance was estimated by the homeostasis model assessment (HOMA-IR), free leptin index was calculated.Results. In the obese group 90% of patients had lower than recommended level of 25(OH)D, in the control group – 75%. In all investigated groups significant negative correlations between 25(OH)D and insulin, HOMA-IR, leptin, and free leptin index were found but in obese subjects this correlations were not observed. There were significant negative correlations between serum calcium and BMI, insulin, HOMA-IR, leptin, and free leptin index and a significant positive correlation between serum calcium and leptin receptor in all investigated groups. In obese subjects there were correlations between calcium levels and soluble leptin receptor as well as free leptin index.Conclusions. Vitamin D deficiency and insufficiency are common in obese and normal weight subjects. There is a lack of correlation between 25(OH)D concentration and insulin resistance parameters and leptin in obese subjects. Vitamin D may impact leptin activity through calcium concentration.
Authors and Affiliations
Magdalena Walicka, Wojciech Bik, Ada Sawicka, Ewa Wolińska-Witort, Małgorzata Kalisz
Keywords
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