Vitamin D in allergic disorders
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Vitamin D is a factor that plays a significant role in calcium-phosphate balance. It has an effect on bone metabolism and also has modulator and anti-inflammatory activity. It is claimed that vitamin D inhibits immunological reactions with Th1 and Th17 lymphocytes. The influence of vitamin D on Th2 lymphocytes is not clear. The main effect of vitamin D is probably the activation of Treg lymphocytes. It was observed that vitamin D had a beneficial influence on diseases connected with excessive activation of Th1 lymphocytes, such as multiple sclerosis, rheumatoid arthritis, non-specific enteritis, diabetes type 1 or psoriasis. The role of vitamin D in allergic diseases, in which increased activation of Th2-dependent reactions are of great importance, is controversial. However, due to a wide range of vitamin D activity, this view seems to be simplified. A beneficial effect on the course of allergic diseases was observed in up-to-date studies although the role of vitamin D in their pathogenesis has not been explained yet. On the basis of recent studies and well-known mechanisms of vitamin D activity on particular elements of the immunological system, the influence of vitamin D on the course of chosen allergic diseases, such as allergic asthma, atopic dermatitis and allergic rhinitis was presented considering the possibility of contribution of allergen-specific immunotherapy.
Authors and Affiliations
Joanna Pawlak, Anna Doboszyńska
Keywords
Related Articles
- EP ID EP67487
- DOI -
- Views 150
- Downloads 0
Badanie przydatności specyficznych wskaźników biochemicznych w ocenie funkcji nerek u osób uzależnionych od narkotyków
Interferony: między strukturą a funkcją
Interferony to rodzina białek wytwarzanych przez różnorodne komórki, m.in. w odpowiedzi na infekcję wywołaną przez wirusy. Obecnie rozróżniamy trzy typy interferonów. Sklasyfikowano je na podstawie sekwencji nukleotydów,...
Material properties of periodontal ligaments
The mechanism of orthodontic teeth movement is not entirely explained. The principal reaction on tissues at the cellular and molecular level is initiated by the force applied to the tooth crown and transferred in turn up...
The importance of ADAM family proteins in malignant tumors
Increasing numbers of reports about the role of adamalysins (ADAM) in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described....
Targeted therapy with monoclonal antibodies: Do we observe progress in the management of female genital tract cancers?
Targeted therapy with monoclonal antibodies (moAbs) has become a valuable supplementation for classic chemo- and radiotherapy. The first part of this review presents in a condensed way the characteristics and mechanism o...