Vitamin D, sex hormones and anaemia in men – is there an influence of cholecalciferol supplementation on haemoglobin concentrations or regulation of sex hormones in male haemodialysis patients? A pilot study
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 10
Abstract
Introduction. Active metabolites of vitamin D, as well as androgens, may play a substantialrole in the correction of anaemia caused by chronic kidney disease.Aim. Aim of the study was to analyze the association among vitamin D metabolite– 25(OH)D, sex hormones and anaemia and assess the influence of vitamin D supplementationon haemoglobin concentrations, and sex hormones levels in male haemodialysispatients.Material and methods. The study was performed in male patients on haemodialysisat the Diaverum Dialysis Unit at Cegłowska Street in Warsaw. In 18 eligible patients aged35-65 who gave informed consent, out of the total of 81, concentrations of 25(OH)D weremeasured. All patients had vitamin D deficiency. Thus, in all patients included in the studycholecalciferol was supplemented for three months in the dose adjusted to the vitamin Ddeficiency. During the study the complete blood count, parameters of iron, calcium andphosphate homeostasis, and concentrations of sex hormones were measured.Results. Normalization of 25(OH)D concentration was achieved in 11out of 16 patientswho completed the study (68.75%). In 8 patients (50%) a significant increase in haemoglobinconcentration was observed (P = 0.001). Baseline concentrations of 25(OH)D correlatedstrongly with total testosterone levels and weakly with haemoglobin concentrations.Moreover, free testosterone index (FTI) moderately correlated with haemoglobin concentrations.Substantial increase in androstenedione concentrations and a decrease in LH,but no significant changes in testosterone concentrations or FTI values were observedduring cholecalciferol supplementation.Conclusions. Cholecalciferol supplementation in vitamin D deficient men on haemodialysiseffectively normalized its serum concentration. Strong correlation between 25(OH)Dand testosterone concentrations may suggest pathophysiologic association, however, theinfluence of vitamin D supplementation on testosterone and haemoglobin levels seemsclinically negligible.
Authors and Affiliations
Katarzyna Chmiel-Majewska, Dorota Daniewska, Grzegorz Misiorowski, Wojciech Zgliczyński, Ryszard Gellert
Keywords
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