Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Journal Title: International Journal of Nutrition Sciences - Year 2017, Vol 2, Issue 3
Abstract
Current results from clinical trials about vitamin E effects on adiponectin are ambiguous. Therefore, we conducted a meta-analysis of available RCTs to resolve this inconsistency. The systematic search was performed in several databases including SCOPUS, PubMed- Medline, and Google Scholar until October 1st, 2017. We used fixedeffects model in combination with mean difference (MD) and 95% confidence intervals (CI) for the analysis of data. Meta-analysis of 6 RCTs (9 treatment arms) showed a significant increase in circulating adiponectin levels (MD: 0.36 ug/ml, 95% CI: 0.16 to 0.56; p<0.001), following vitamin E supplementation. In sub-group analysis, a significant increasing effect was observed only in trials with ≥400 mg/day dosage (MD: 0.78 ug/ml, 95% CI: 0.31, 1.24, p=0.001) and those trials lasting ≥6 months (MD: 0.58 ug/mL, 95% CI: 0.29, 0.86, p<0.001). In meta-regression, there was association between changes in adiponectin concentrations and duration of supplementation. Our findings showed the significant increase effect of vitamin E supplementation on circulating adiponectin levels, however a significant increasing effect was observed at doses above 400 mg/day and when supplementation lasting over 6 months.
Authors and Affiliations
Mohsen Mohammadi-Sartang, Arash Dashtabi, Zohreh Mazloom
Keywords
Related Articles
- EP ID EP281464
- DOI -
- Views 69
- Downloads 0
The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia
Background: Vitamin D supplementation was shown to reduce obesityrelated oxidative stress and inflammation among overweight or obese people as well as improving glycemic control and lipid profile in type 2 diabetic (T2D)...
Predictive Power of Visceral Adiposity Index and Model of Adipose Distribution in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
Background: Nowadays, non-alcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome. Visceral adiposity index (VAI) and model of adipose distribution (MOAD) are novel indicato...
The Concentration of Mercury, Cadmium and Lead in Muscular Tissue of Fishes in Khersan River
Background: Aquatic ecosystems including fish in rivers may be widely contaminated by heavy metals released into waters from industrial, agricultural and other human activities.This study aimed to investigate the level o...
The Prevalence of Malnutrition in Elderly Members of Jahandidegan Council, Shiraz, Iran
Background: The risk of malnutrition is increased in elderly because of insufficient food intake, debilitating diseases, social loneliness, and economical limitations. It not only increases the susceptibility to the deve...
Effect of Emulsion Condition of Oil Phase on Microstructure and Anti-Fungal Properties of Emulsified Films Based on Carboxymethyl Cellulose
Background: A comparison of the various microstructural and antimicrobial properties of emulsified films indicated significant differences. This study aimed to determine the effect of emulsion condition of oil phase on m...