ВИЗНАЧЕННЯ ГЛИБИНИ ПРОНИКНЕННЯ ФАРМАКОЛОГІЧНИХ ПРЕПАРАТІВ У БІОЛОГІЧНИЙ ОБ`ЄКТ ПРИ УЛЬТРАФОНОФОРЕЗІ
Journal Title: BULLETIN of Kyiv Polytechnic Institute. Series INSTRUMENT MAKING - Year 2018, Vol 56, Issue 56
Abstract
In the article are given the results of studying the effect of ultrasonic vibrations of varying intensity, frequency and waveform on the depth of penetration of pharmaceuticals over time into biological tissue. Established dependence will allow to control and provide for the introduction of the drug, its penetration into the deeper layers of tissue. The permeability of human skin is of great interest for physiotherapy, since it is based on the definition of action and therapeutic effect of some physical methods of treatment. The research objective follows from the directions of development of the method of non-invasive drug administration, since the described technologies for delivering the active substance are more effective and safe and are analogous to invasive injections. The task of the study was solved by establishing the laws of the depth and rate of penetration of pharmacological preparations into biological tissue, depending on the parameters and shape of ultrasonic vibrations. For a practical justification of the effectiveness of ultrasound during phonophoresis, a study was conducted with a series of measurements on biological tissue using pharmacological preparations. The method of phonophoresis should be considered not only as a means of delivering pharmacological substances into the body, but also as a physico-pharmacological method for the treatment and prevention of diseases, in which ultrasound plays an important role as a therapeutic factor. The results will be further used to improve the mathematical model and the creation of an algorithm that can predict the direction and speed of passage of pharmaceutical substances when exposed to ultrasound of a certain intensity, shape and time, in the future can be used to create a physiotherapeutic apparatus.
Authors and Affiliations
Mykola Tereshchenko, Grigory Tymchik, Serhii Pankov
Keywords
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- EP ID EP568440
- DOI 10.20535/1970.56(2).2018.152483
- Views 169
- Downloads 0
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