WAYS OF NEUTRALIZING AMMONIA IN THE HUMAN BODY, URINARY SYNTHESIS. ORNITHINE CYCLE
Journal Title: International scientific journal Science and Innovation - Year 2024, Vol 3, Issue 4
Abstract
Ammonia is a key metabolite derived from amino acid metabolism and breakdown of nitrogenous substances in the gut,1,2 and present hypotheses suggest that it is of central importance in the pathogenesis of hepatic encephalopathy. Current therapeutic strategies are directed towards reducing circulating concentrations of ammonia. The two main pathways of ammonia detoxification are synthesis of urea and glutamine. In the physiological state, the liver is central in urea synthesis and this forms the basis of ammonia removal.3 The other organs capable of metabolising ammonia are the brain and skeletal muscle through synthesis of glutamine. In the presence of liver disease however, loss of functional liver mass and portocaval shunting may contribute to increased ammonia levels in plasma, thus predisposing to hepatic encephalopathy. In cirrhotic patients, skeletal muscles play an important role in the detoxification of ammonia to glutamine.4 Glutamine synthesis is however only a temporary method of ammonia detoxification. To remove ammonia from the body in a situation when urea synthesis is compromised (as happens in liver disease) requires transport of glutamine to the kidney, where it is metabolised to release ammonia, which is then excreted in urine.
Authors and Affiliations
Ayyubova Sevinch Murodjon kizi, Hakimova Fayyoza Jahongir kizi, Mukhamedova Sevara Nigmatulla kizi
Keywords
Related Articles
- EP ID EP735567
- DOI 10.5281/zenodo.11094551
- Views 71
- Downloads 0
METHODS OF TEACHING RUSSIAN LANGUAGE THROUGH VISUAL MEANS FOR STUDENTS OF NON-LINGUISTIC GROUPS
This article explores the effectiveness of visual tools in teaching Russian to students of a non-linguistic group. Recognizing the challenges faced by students who do not have a strong background in language acquisition,...
THE IMPACT OF ENVIRONMENTAL POLICY ON PRICING IN THE OIL AND GAS INDUSTRY
The relevance of the article is due to the growing importance of sustainable development and environmental responsibility in the global economy. Environmental policies, including carbon taxation, emission quotas and inve...
ACTUAL ISSUES OF ORGANIZING NURSING CARE BY ESSENTIAL ARTERIAL HYPERTENSION IN ADOLESCENTS IN PRIMARY HEALTH CARE
The given article describes a preventive examination and its results conducted at secondary school N.46 of Kibray district, Tashkent region. The purpose of the study was based on a comprehensive assessment of the activit...
FERGHANA MEDICAL COMMUNITY AND PUBLIC HEALTH ISSUES
In this article, on the basis of historical and scientific sources, the activities of foreign health professionals of Ferghana Medical Community, which was established in the Fergana Valley in the late 19th and early 2...
STUDY OF THE NAME OF MEASURES IN RUSSIAN
This article is about the naming of measures in Russian. The characteristic of the naming and use of measures in the Russian language is given