What Should the Hemoglobin A1c Level Goal be in Diabetics?
Journal Title: International Journal of Diabetology & Vascular Disease Research (IJDVR) - Year 2015, Vol 3, Issue 10
Abstract
An increased hemoglobin A1c level in patients with diabetes mellitus is associated with an increased incidence of ischemic stroke, increased severity of coronary artery disease, and an increased severity of peripheral arterial disease. Results from 5 prospective clinical trials which randomized diabetics to intensive blood glucose control or to standard blood glucose control and one retrospective observational study of 26,673 diabetics are discussed. The 5 clinical trials were the United Kingdom Prospective Diabetes Study, the Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Study, the Action to Control Cardiovascular Risk in Diabetes Study, the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modifies-Release Controlled Evaluation Study, and the Veterans Affairs Diabetes Trial. Severe hypoglycemia may be associated with cardiovascular events and mortality. Recommendations from the 2007 scientific statement from the American Heart Association and the American Diabetes Association, the 2011 American Heart Association/American College of Cardiology Foundation secondary prevention guidelines in patients with coronary and other atherosclerotic vascular disease, the 2013 American Diabetes Association guidelines, and the 2013 American Geriatrics Society guidelines for improving the care of older adults with diabetes mellitus are also discussed.
Authors and Affiliations
Wilbert S. Aronow
Keywords
Related Articles
- EP ID EP198915
- DOI 10.19070/2328-353X-1500029
- Views 86
- Downloads 0
Growth Differentiation Factor-15 (GDF-15) a Precursory Biomarker for Diabetic Patients with Coronary Artery and Chronic Kidney Disease
Background: Growth-differentiation factor-15 (GDF-15) is emerging as an important biomarker, thus the current study aimed to determine the levels of GDF-15 among, T2DM subjects with chronic kidney disease (CKD) and coron...
Walking Economy is Impaired in Older Men and Women with Type 2 Diabetes
Objective: We compared the walking economy in older participants with and without type 2 diabetes. Methods: Walking economy was determined in 115 older participants with type 2 diabetes and 130 older control participants...
Magnesium Deficiency Results in Oxidation and Fragmentation of DNA, Down Regulation of Telomerase Activity, and Ceramide Release in Cardiovascular Tissues and Cells: Potential Relationship to Atherogenesis, Cardiovascular Diseases and Aging
There is a growing awareness that dietary deficiency of magnesium is becoming a serious problem, particularly in the Western World. Disturbances in diet are known to promote lipid deposition in the arterial walls and acc...
Diabetes: A Large Global Catastrophe in Perspective
Diabetes: A Large Global Catastrophe in Perspective
On The Horizon: New Oral Therapies for Type 2 Diabetes Mellitus
The first documented case of diabetes mellitus occurred earlier than 4000 BC. Since then, many of the brightest minds in medicine have dedicated their time and effort toward developing treatments that can reverse the cou...