White Oyster Mushroom Effect Of Lowering Cholesterol Levels And Prevention Atherosclerosis In Wistar Male Rats Are Given High Cholesterol Feed.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Atherosclerosis is a degenerative disease which onset can be accelerated by consuming foods high cholesterol. To prevent the formation of atherosclerosis is reduce of cholesterol levels. Objective: To determine the effect of oyster mushroom extract or residue in preventing the formation of atherosclerosis by lowering cholesterol and LDL levels.Preparation of the extract by maceration method using ethanol 96%. Animals using 24 male rats were divided into four groups, each group consisting of 6 animals. Group 1 (given regular feed), group 2 (fed with high cholesterol), group 3 (fed with high cholesterol, ethanol extract of oyster mushrooms 250 mg / kg bw once a day), group 4 (fed with high cholesterol, residue ethanol ekstract of oyster mushrooms 250 mg / kg bw once a day). Parameters measured were cholesterol, LDL, body weight, foam cells and the thickness of intima layer. Cholesterol levels, LDL is measured every week, foam cells and the thickness of the intima layer examined in histopathology at the end of the experiment. Analysis of data using one-way ANOVA. In the study showed that extract and residue of oyster mushrooms can prevent raising levels of cholesterol, LDL, foam cell formation, and thickening of the intima. The results indicate that extract ethanol of oyster mushrooms and the residue is useful for preventing atherosclerosis and also to lower cholesterol levels and LDL.
Authors and Affiliations
Ernawati . , Hakim Bangun, Delyuzar3 . , Jamaludin Sitorus, Yunita Sari Pane
Keywords
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- EP ID EP392088
- DOI 10.9790/3008-1205078189
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