WHO Guided Real Time Stability Testing on Shankhpushpi Syrup
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2017, Vol 5, Issue 1
Abstract
Shankhpushpiis widely used herb in numerous CNS active Ayurvedic formulations, which are consumed by population of all age groups. The present study is designed to evaluate the stability of commercially available shankhpushpi syrup as per WHO guidelines. The study was conducted under long term conditions for 12 months on three different batches of the product. An HPLC-UV method was developed and validated to determine the marker (scopoletin) content in the stability samples. Peak purity was determined using HPLC-PDA analysis. Each stability sample was investigated for any change in physical, chemical and biological parameters with respect to control sample. The product was found to be stable in terms of physical parameters whereas significant change was observed in total phenolic content and content of scopoletin. The antioxidant, acetylcholine esterase inhibitory and antianxiety activities of the stability samples decreased with respect to control sample. Moreover, there was significant variation in chemical and biological parameters among the batches. The findings suggested that the product was unstable and further studies are required to be conducted in order to determine the shelf life of the product.
Authors and Affiliations
Astha Jain , Jasmeen Kaur , Nancy, Yogita Bansal , Balraj Saini , Gulshan Bansal
Keywords
Related Articles
- EP ID EP596719
- DOI 10.15415/jptrm.2017.51001
- Views 140
- Downloads 0
Formulation, Optimization and Evaluation of Sustained Release Microspheres using Taguchi Design
The aim of present study is to prepare microspheres of eudragit RL 100 loaded with Nefopam Hydrochloride by single emulsion solvent evaporation technique. Taguchi L9 orthogonal array design has been used to optimize the...
Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini
An isocratic HPLC method was developed for standardization of five commercially available products containing S. cumini seeds (DIABECON, MADHULENE, HYPONIDD, D-FIT and DIABEGON)using methylxanthoxylin (MXX)as marker. The...
Antiamnesic Activity of Extracts and Fraction of Desmodium Gangeticum
Desmodium gangeticum D.C. (Salpani; family – Papilionaceae) has been traditionally used in the treatment of various ailments especially in dementia. Thus, it was planned to screen antiamnesic activity of D. gangeticum to...
Assessment of Suspending Properties of Katira Gum: Formulation and Evaluation of Nimesulide Suspension
There are several hydrophilic polymers that have been employed as suspending agents in pharmaceutical suspensions due to their ability to form colloidal gel in aqueous medium. In the present study, katira gum obtained fr...
Toxicological Evaluation of Crude Alkaloid Fraction Isolated From Indian Folklore Plant Telosma Pallida (Roxb) wg Craib Root Using Probit Value Analysis
Present study first time reported the toxicological profile of Telosma pallida (TP) crude alkaloid fraction (CAF) isolated from the root of the climber plant by brine shrimp lethality test (BLT). Telosma pallida is a per...