Wnt signaling pathway – its role in regulation of cell metabolism
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
The Wnt signaling pathway plays an important role in morphogenesis, differentiation, cell survival and proliferation. Wnt activators are secreted proteins that work in an auto-, para- and endocrine manner and their synthesis, secretion and transport are tightly regulated. Frizzled/LRP is the main receptor complex in the canonical Wnt pathway. Its activation triggers β-catenin translocation to the nucleus and increases activity of TCF transcription factor. Disruption in Wnt signaling has been found in many pathophysiological states such as different types of cancer, neurodegenerative diseases and metabolic disorders. Recent studies revealed the important role of Wnt signaling in maintaining carbohydrate and lipid homeostasis. Activation of the Frizzled/LRP receptor complex leads to increase in the activity of transcription factors and nuclear receptors that regulate expression of genes involved in lipid utilization (PPARδ, RAR, LXR) and inhibits adipogenesis. The Wnt signaling pathway is also involved in the regulation of gluconeogenesis and glycolysis. This review summarizes the current state of knowledge about mechanisms that regulate canonical Wnt signaling and its role in cell metabolism regulation.
Authors and Affiliations
Kamil Koziński, Agnieszka Dobrzyń
Keywords
Related Articles
- EP ID EP67196
- DOI -
- Views 132
- Downloads 0
Rola krążących cząsteczek mikroRNA u pacjentów hemodializowanych
Rola manganu w etiopatogenezie i prewencji wybranych schorzeń
Mangan (Mn) należy do pierwiastków śladowych, niezbędnych do prawidłowego rozwoju i wzrostu organizmu. Podaż tego składnika mineralnego zgodna z zapotrzebowaniem organizmu determinuje prawidłowy metabolizm większości sk...
Znaczenie kliniczne białek wiążących kwasy tłuszczowe (FABPs)
Nadmierne stężenie wolnych kwasów tłuszczowych jest toksyczne dla komórki. W organizmie ludzkim wewnątrzkomórkowo występują małe cytoplazmatyczne białka (FABPs – fatty acid binding proteins), które wiążą długołańcuchowe...
The importance of pharmacogenetic tests in evaluation of the effectiveness of methotrexate treatment in rheumatoid arthritis (part 1)
Methotrexate (MTX) is still the gold standard in the treatment of rheumatoid arthritis and is used worldwide in more than 0.5 million patients with RA. Much hope is currently associated with the individualization of th...
The importance of selenium in Hashimoto’s disease
The aim of this study was to present the current state of knowledge on the role of selenium in the treatment of Hashimoto’s disease. In recent years, the number of cases of autoimmune Hashimoto’s thyroiditis – a chronic...