Wykorzystanie jednoczesnych rejestracji sluchowych potencjaidow korowych i funkcjonalnego rezonansu magnetycznego do badania procesOw otrodkowej czetci ukiadu sluchowego — wyniki wstepne
Journal Title: Otolaryngologia Polska - Year 2011, Vol 65, Issue 3
Abstract
SUMMARY Introduction: Processing of auditory information in central nervous system bases on the series of quickly occurring neural processes that cannot be sepa-rately monitored using only the fMRI registration. Simultaneous recording of the auditory evoked potentials, characterized by good temporal resolution, and the functional magnetic resonance imaging with excellent spatial resolution allows studying higher auditory functions with precision both in time and space. The aim of the study: was to implement the simultaneous AEP-fMRI record-ings method for the investigation of information processing at different levels of central auditory system. Material and methods: Five healthy volunteers, aged 22-35 years, partici-pated in the experiment. The study was performed using high-field (3T) MR scanner from Siemens and 64-channel electrophysiological system Neuro-scan from Compumedics. Auditory evoked potentials generated by acoustic stimuli (standard and deviant tones) were registered using modified odd-ball procedure. Functional magnetic resonance recordings were performed using sparse acquisition paradigm. The results of electrophysiological registrations have been worked out by determining voltage distributions of AEP on skull and modeling their bioelectrical intracerebral generators (dipoles). FMRI ac-tivations were determined on the basis of deviant to standard and standard to deviant functional contrasts. Results obtained from electrophysiological studies have been integrated with functional outcomes. Morphology, amplitude, latency and voltage distribution of auditory evoked potentials (P1, N1, P2) to standard stimuli presented during simul-taneous AEP-fMRI registrations were very similar to the responses obtained outside scanner room. Significant fMRI activations to standard stimuli were found mainly in the auditory cortex. Activations in these regions corresponded with N1 wave dipoles modeled based on auditory potentials generated by standard tones. Auditory evoked potentials to deviant stimuli were recorded only outside the MRI scanner. However, deviant stimuli induced significant fMRI activations. They were observed mainly in the anterior cingulate gyrus, insula and parietal lobes. These regions of the brain are related to attention and decision-making processes. Conclusions: The results showed that applied paradigm is suitable for investi-gation of acoustic processing on the level of auditory cortex. Technique of the simultaneous AEP-fMRI registrations seems to be promising for investigation of more complex nervous processes in central auditory system with good temporo-spatial resolution
Authors and Affiliations
Rafał Milner, Mateusz Rusiniak, Tomasz Wolak, Ewa Piątkowska-Janko, Patrycja Naumczyk, Piotr Bogorodzki, Andrzej Senderski, Małgorzata Ganc, Henryk Skarżyński
Keywords
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