XYLAZINE-KETAMINE ANAESTHESIA; COMPARATIVE STUDIES IN MALE AND FEMALE CANE RATS (THRYONOMYS SWINDERIANUS)

Abstract

Objective: Domestication of the Cane rats is on-going globally and might replace the conventional rodents used in biomedical research in future. However, the paucity of information on adequate anaesthesia vis-a-vis xylazine-ketamine drug combination in the male and female Cane rats warranted this study.Methods: Six adult Cane rats {1.8±0.7 kg body weights (bwt.)} assigned into group A (Female) and group B (Male) of three rats each was used for the study. Each animal was premedicated with atropine sulphate (0.05 mg/kg bwt), and later administered xylazine (10 mg/kg bwt) and ketamine (100 mg/kg bwt) intramuscularly. Meanwhile, anaesthetic characteristics and physiologic indices of anaesthesia were monitored.Results: Results obtained showed that the physiologic indices; open eyelids, smooth induction and recovery, skeletal muscle relaxation and somatic analgesia were observed in all the animals, however, the anaesthetic indices; time to induction, time to standing, duration of analgesia and duration of recumbency showed marked sex variations. The mean values for the duration of analgesia and recumbency were significantly elevated (P<0.05) in group B as compared with group A. Similar trend was seen for time to standing, but, it was non-significant (P>005). However, time to induction mean value for group A was non-significantly increased (P>005) when compared with group B. The heart rate, respiratory rate and rectal temperature mean values decreased in both groups non-significantly (P>0.05).Conclusion: Conclusively, the xylazine-ketamine combination produced anaesthesia in Cane rat and the combination is more tolerated in the male Cane rats than the female Cane rats.

Authors and Affiliations

Olatunji-akioye A, Ojiaka H N, Samuel E. S

Keywords

Related Articles

IMPACTS OF DIFFERENT CONCENTRATIONS OF AQUEOUS GREEN TEA EXTRACT ADMINISTERED DURING METHOTREXATE TREATMENT ON SOME SELECTED BLOOD INDICES IN RATS

Objective: This study was designed to investigate the impacts of administering of different concentrations of Aqueous Green Tea Extract (AGTE) (0.625, 1.25 or 2.5%) during Methotrexate (MTX) treatment, and continued for...

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PIPERAQUINE PHOSPHATE AND DIHYDROARTEMISININ IN BULK

High Performance Liquid Chromatography (HPLC) methods are described for determination of drugs as a single or in combination in bulk or pharmaceutical formulation. The objective of the present study was to develop and va...

ISOLATION OF CYTOTOXIC CONSTITUENT FROM BIOACTIVITY GUIDED FRACTION OF ALYSICARPUS MONILIFER L. (DC.)

Objective: Alysicarpus monilifer (Family Papilionaceae) has been used in the Indigenous system of medicine in tumor removal. The present study was designed to isolate and identify the constituent responsible for cytotoxi...

MICROBIAL METABOLISM OF AN ANTI-HIV AND ANTI-MALARIAL NATURAL PRODUCT ANDROGRAPHOLIDE

Objective: Andrographolide (1), the main crystalline bitter principle of Andrographis paniculata nees. (also known as rice bitter in the West Indies) was first isolated by Gorter, and characterized as trihydroxy lactone....

STUDIES ON ANTIOXIDANT ACTIVITIES OF SIX CULTIVARS OF PIPER BETLE LINN

Objective: To study the existence of difference or similarity on total phenolic content, flavonoid content and antioxidant properties among different cultivars of Piper betle L.Methods: The methanolic extracts of six dif...

Download PDF file
  • EP ID EP575755
  • DOI 10.22159/ijpps.2017v9i1.12140
  • Views 67
  • Downloads 0

How To Cite

Olatunji-akioye A, Ojiaka H N, Samuel E. S (2017). XYLAZINE-KETAMINE ANAESTHESIA; COMPARATIVE STUDIES IN MALE AND FEMALE CANE RATS (THRYONOMYS SWINDERIANUS). International Journal of Pharmacy and Pharmaceutical Sciences, 9(1), 52-55. https://europub.co.uk/articles/-A-575755