YKL-40 in the diagnosis, prediction of prognosis, and platinum sensitivity in serous epithelial ovarian cancer
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2018, Vol 15, Issue 3
Abstract
Objective: To evaluate the use of YKL-40 in the discrimination between benign and malignant adnexal mass and to determine its prognostic value in assessing residual tumor after primary cytoreduction and platinum sensitivity in serous epithelial ovarian carcinoma (EOC). Materials and Methods: During the three years from January 2015 to December 2017, a nonconsecutive series of 100 patient (60 malignant, 40 benign) who underwent surgery for an adnexal mass were enrolled in the study. Preoperatively, serum samples were collected for YKL-40 level analysis. Results: YKL-40 [receiver operator characteristics (ROC)-area under curve (AUC)=0.83] was a significantly better predictor of EOC than cancer antigen-125 (ROC-AUC=0.75). Using a cut-off for YKL-40 of 47.7 ng/mL had a sensitivity of 80% and a specificity of 70%. Higher serum YKL-40 levels were associated with advanced stage, higher grade, residual tumor after primary cytoreduction and recurrence. Platinum-sensitive patients had significantly elevated levels of YKL-40 compared with platinum-resistant or refractory patients. Conclusion: The results obtained from our study support the use of serum YKL-40 for the discrimination between malignant and benign ovarian tumors. YKL-40 levels in patients with serous EOC may also predict disease residual disease after primary cytoreduction and recurrence. Further studies are needed to understand the relationship between YKL-40 and platinum sensitivity.
Authors and Affiliations
İlker Kahramanoğlu, Nedim Tokgözoğlu, Hasan Turan, Veysel Şal, Gönül Şimşek, Remise Gelişgen, Tugan Beşe, Fuat Demirkıran, Macit Arvas, Hafize Uzun
Keywords
Related Articles
- EP ID EP379379
- DOI 10.4274/tjod.28459
- Views 119
- Downloads 0
Anemia prevalence at the time of pregnancy detection
Objective: Anemia in the first trimester of pregnancy is the situation as described by the World Health Organization when the level of hemoglobin (Hb) is less than 11 g in 100 cc of blood. The prevalence of this problem...
Features of ovarian Brenner tumors: Experience of a single tertiary center
Objective: Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors. Materials and Methods: The clinical features of 22 patients who were treated i...
Fertility preservation in male patients subjected to chemotherapy; innovative approaches for further progress
About 4% of male patients with cancer are under the age of 35 years. With the current increase in efficacy and safety of therapies, a growing number of young adults can achieve long-term survival. In male patients receiv...
Anatomic structure of the internal iliac artery and its educative dissection for peripartum and pelvic hemorrhage
The abdominal aorta is divided into two parts (right and left) at the level of the fourth-fifth lumbar vertebra and called the common iliac artery. Anterior to the sacroiliac joint, common iliac arteries are divided into...
Sleep quality of endometrial cancer survivors and the effect of treatments
Objective Sleep disorders affect 54.9% of gynaecologic cancer survivors. The effect of treatment methods on sleep quality is not clear. This study evaluated the sleep quality of survivors of endometrial cancer and compar...