ЗНАЧЕННЯ МАРКЕРА КІ -67 ПРИ ПЛАНУВАННІ СИСТЕМНОЇ РАДІОНУКЛІДНОЇ ТЕРАПІЇ У ХВОРИХ З МНОЖИННОЮ КІСТКОВОЮ ПАТОЛОГІЄЮ РАКУ МОЛОЧНОЇ ЗАЛОЗИ
Journal Title: World Science - Year 2018, Vol 3, Issue 2
Abstract
The article is dedicated to the efficiency analysis of the systemic radionuclide treatment of multiple bone metastases in patents with breast cancer considering initial level of Ki-67 marker. It has been registered that patents who had high level of Ki-67 indicated at the time of breast cancer diagnosis had more severe course of disease further on during the course of systemic radionuclide therapy of multiple bone pathology vs. the group of patients with lower level of Ki-67. It has been reflected via faster development of bone dissemination process, and lower efficiency of treatment: reduction of remission period and fast appearance of foci of metastasis outside of bone system. Taking into account potentially shorter period available for systemic radionuclide therapy, and in order to ensure high-quality remission period it has been proposed to use radiopharmaceuticals with longer half-life period and reduction of intervals between therapy under the condition of preservation of bone marrow hematopoiesis, or by increasing of treatment doses of radionuclides with low energy.
Authors and Affiliations
М. М. Фірсова
Keywords
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