Zoonotic Disease A Highly Conservedbinding Region of Angiotensin Converting Enzyme2as a Receptor for Severe Acute Respiratory Syndromecoronavirus 2 SARS Cov 2 between Humans and Mammals
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2020, Vol 5, Issue 1
Abstract
A case of the new coronavirus severe acute respiratory syndromecoronavirus 2 SARS CoV 2 infection transmitting from a human to a domestic cat was reported on March 27, 2020 in Belgium. Cases of SARS CoV 2 infection being transmitted from owners to their dogs have also been reported. For the first time, however, a case of SARS CoV 2 transmission from a human to a domestic cat has been confirmed. A tiger kept at a zoo in New York was also reportedly infected with SARS CoV 2 it is believed that the virus was transmitted to the tiger from infected caretakers. Therefore, we examined the homology of the angiotensin converting enzyme2 ACE2 molecule, a receptor for the spike glycoprotein on the virionsurface of SARS CoV 2, between humans, dogs, cats, and other mammals. We found that the binding region of theACE2 molecule with the SARS CoV 2 spike glycoprotein has high homology between humans, dogs, cats, tigers, and other mammals. Although the transmission of human coronavirus to petsor animals is rare, SARS CoV 2 transmission from animals or pets to humans have not yet been demonstrated. The Belgian Health Service considers zoonotic infection as a special case. However, the Belgian Health Service has suggested individuals with SARS CoV 2 to also avoid contact with pets or other animals. Takuma Hayashi | Masaki Mandai | Nobuo Yaegashi | Ikuo Konishi "Zoonotic Disease: A Highly Conservedbinding Region of Angiotensin-Converting Enzyme2as a Receptor for Severe Acute Respiratory Syndromecoronavirus 2 (SARS-Cov-2) between Humans and Mammals" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, URL: https://www.ijtsrd.com/papers/ijtsrd38191.pdf Paper URL : https://www.ijtsrd.com/medicine/other/38191/zoonotic-disease-a-highly-conservedbinding-region-of-angiotensinconverting-enzyme2as-a-receptor-for-severe-acute-respiratory-syndromecoronavirus-2-sarscov2-between-humans-and-mammals/takuma-hayashi
Authors and Affiliations
Takuma Hayashi | Masaki Mandai | Nobuo Yaegashi | Ikuo Konishi
Keywords
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