Experimental Biomedical Research

Experimental Biomedical Research

Basic info

  • Publisher: Prof. Dr. Hayrettin Ozturk
  • Country of publisher: turkey
  • Date added to EuroPub: 2019/Sep/03

Subject and more

  • LCC Subject Category: Biological Sciences, Medicine
  • Publisher's keywords: Biomedical Sciences, Medicine
  • Language of fulltext: english

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  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: CC BY-NC
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2018
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '38' articles

A review of cardiovascular disease induced by radiation

A review of cardiovascular disease induced by radiation

Authors: Isa Sincer, M.D., Aslı Kurtar Mansuroglu
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Abstract

Cardiovascular diseases are still in the 1st place in the world among cause of deaths. Data accumulates about publications investigating the effect of radiation on cardiovascular disease. Ionized radiation is used for diagnosis and treatment of many disease, recently. As for invasive cardiology; coronary artery disease, cardiac valve diseases, electrophysiological studies require radiation assistance. It is very important for invasive cardiologists to know the cardiovascular adverse effects of radiation and radiation protection methods.

Keywords: Cardiovascular disease; radiation; invasive cardiology
Serum Uric acid is correlated with HbA1c levels in type 2 diabetes mellitus

Serum Uric acid is correlated with HbA1c levels in type 2 diabetes mellitus

Authors: Tuba Taslamacioglu Duman, Mehmet Zahid Kocak, Burcin Meryem Atak, Edip Erkus
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Abstract

Aims: Uric acid is the product of purine metabolism and elevated serum uric acid levels are associated with many metabolic conditions. In present retrospective analysis, we aimed to compare serum uric acid levels of well controlled type 2 diabetic subjects to those of poorly controlled type 2 DM patients. Methods: Medical database of type 2 diabetic subjects whom admitted to outpatient clinics of our institution, between January 2017 and August 2017, were retrospectively analyzed. Patients with a HbA1c level lower than 7,5% were classified as well controlled and others were classified as poorly controlled type 2 DM group. Uric acid levels of the groups were compared. Results: Serum uric acid level of well controlled and poorly controlled diabetics were 4.1 (2,8-5,9) mg/dl and 5,9 (4-9,6) mg/dl, respectively. The difference was statistically significant (p<0.001). A Pearson’s correlation test was revealed that serum uric acid was strongly and positively correlated with HbA1c (r=0.81, p<0.001). Conclusion: Serum uric acid levels worsen in poorly controlled type 2 diabetic subjects. Since HbA1c levels reflects changes in 3 months period, variations in serum uric acid levels could be used as a predictor of diabetic control level in shorter time periods.

Keywords: uric acid, HbA1c, type 2 diabetes mellitus
The effects of treadmill exercise on oxidative stress in Mongolian gerbils with penicillin-induced epilepsy

The effects of treadmill exercise on oxidative stress in Mongolian gerbils with penicillin-induced epilepsy

Authors: Ayhan Cetinkaya, Serif Demir, Hayriye Orallar, Yildirim Kayacan, Ersin Beyazcicek
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Abstract

Aim: To evaluate the role of treadmill exercise on the oxidative stress in Mongolian gerbils with penicillin-induced epilepsy. Methods: This experimental study included 18 male Mongolian gerbils which were divided into three groups; sham-control group, penicillin group (500 units) and exercise + penicillin (500 units) group. Each animal group was composed of six Mongolian gerbils. The epileptiform activity was verified by electrocorticographic recordings. Results: The latency of the penicillin+exercise group was longer than the penicillin group, but this difference was not statistically significant. Following the penicillin administration, spike wave frequencies of epileptiform activity in the 10, 30, and 35 minutes were significantly lower in the penicillin+exercise group, compared with the penicillin group. There were generally significant decreases in the spike wave amplitude medians in the penicillin+exercise groups compared with the penicillin group in all time periods between 0 and 5 minutes. The serum superoxide dismutase, catalase and glutathione peroxidase levels increased in the penicillin+exercise group compared with those in the penicillin group. Conclusion: The results of present study indicate that regular exercise may contribute to the amelioration of epileptic activity by increasing the antioxidant effect.

Keywords: Penicillin-induced epilepsy; treadmill exercise; oxidative stress; Mongolian gerbils
Protective effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion in rats

Protective effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion in rats

Authors: Mehmet Hanifi Okur, Hikmet Zeytun, Erol Basuguy, Gulay Aydogdu, Ulas Alabalık, Ibrahim Kaplan, Sevinc Akdeniz, Serkan Arslan, Bahattin Aydoğdu
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Abstract

Aim: To investigate the effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion (I/R) in rats. Method: Forty male Wistar rats were randomly divided into 4 groups as group I (sham, n=10), group II (control, n=10), group III (I/R-untreated, n=10) and group IV (I/R-cordycepin, n=10). Liver ischemia was induced for 30 min then reperfusion was allowed for 1 h. At the end of the experiment, liver specimens and blood samples were taken for histopathological and antioxidant evaluations, and biochemical analysis. Results: The levels of IL6, IL-1β, and TNFα in the serum and liver tissues were higher in the I/R-untreated group compared to the I/R-cordycepin treated group. In the I/R-cordycepin group, serum MDA levels were decreased compared with the I/R-untreated group. The I/R-cordycepin treated group showed an increase in TAS levels, and a decrease in TOS levels compared with I/R-untreated group. The histopathological injury score were significantly lower in the I/R-cordycepin treated group compared to the I/R-untreated group. In the I/R-untreated group, the integrity of the hepatocyte cell lines deteriorated. Mononuclear inflammatory cells infiltrated the parenchyma regions, the sinuses dilated and there was diffuse congestion Preoperative treatment with cordycepine reduced histopathological abnormalities.

Keywords: Liver ischemia/reperfusion, proinflammatory cytokines, oxidative stress, cordycepin
Surgical treatment with rhomboid excision and Limberg flap technique under spinal anesthesia of 23 young with pilonidal sinus disease

Surgical treatment with rhomboid excision and Limberg flap technique under spinal anesthesia of 23 young with pilonidal sinus disease

Authors: Hulya Ozturk, Hamit Yoldas, Ibrahim Karagoz
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Abstract

Aim: To present the experience of treatment with Limberg flap procedure under spinal anesthesia in 23 young patients with pilonidal sinus disease. Methods: This was a retrospective study of 23 young patients who underwent surgery for pilonidal sinus disease under spinal anesthesia between January 2011 and November 2017 in the Division of Pediatric Surgery. All patients were evaluated for age, sex, clinical diagnosis, and body mass index, and infection, duration of symptoms, treatment, healing time, recurrences, complications and results. Results: Of the 23 patients, 4 (17%) were male, and 19 (83%) were female. The mean age of the patients was 15.21 ± 2.8 years and the mean symptom duration was 4 ± 2.6 months. In 13 patients (56.5%), there was one or more sagittal lines in the midline and the mean sinus number of the patients was 2.12 ± 0.60. Pain was the most important complaint affecting the quality of life of the patient. The mean body mass index was 26.33 ± 2.54 kg / m2, and 47.8% (n = 11) were high BMI and 53.2% were normal BMI. One patient had temporary headache and one patient had urinary retention. Wound infection occurred in 2 patients (8.6%). Recurrence was not observed in patients. Conclusion: In this study, pilonidal sinus disease was treated with Limberg flap procedure under spinal anesthesia. The combination of these two applications in patients with pilonidal sinus may provide significant advantages, such as rapid recovery and short hospital stay, early return to daily activities, low complications, and recurrence rates.

Keywords: Pilonidal sinus, young, Limberg flap, spinal anesthesia, complications
Importance of homogenization in platelet-rich plasma researches

Importance of homogenization in platelet-rich plasma researches

Authors: Ali Gokkaya, Metin Gorgu, Ertuğrul Karanfil, Jehat Kizilkan, Ali Dogan
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Abstract

Aim: To achieve homogenization, one of the most important factors to overcome during platelet-rich plasma (PRP) is standardization phases. Method: We used 10 cc 'BD vacutainer ACD-A' tubes which consisted of 1.5 cc ACD-A. 3 tubes blood was collected from healthy volunteers from 20 to 40 years. All tubes were centrifuged by 180g x 12 min. Then 0.01 ml PRP was collected from just the level of buffy coat. Results: Platelet concentration decreased from buffy coat to top of PPP as expected. If any counting done before homogenization the results will be misleading. Conclusion: When we sample 3 cc PRP homogenized with shaker at 3 point from 3 different point, we see that they are close to each other. It is important that the PRP to be used in the studies must be homogenized before any measurement.

Keywords: Platelet-rich plasma, platelet-poor plasma, homogenization
The association of serological tests and anemia in celiac disease

The association of serological tests and anemia in celiac disease

Authors: Mervan Bekdas, Fatih Unal
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Abstract

Aim: Celiac disease (CD) is a common immune-mediated enteropathy caused by gluten. These patients may apply with many different clinical forms. The aim of this study is to determine the association of serological tests and type of anemia in CD. Methods: Totally117 biopsy proven CD patients aged between 1-17 years were included. Serological and hematological parameters of all patients were studied. Results: Anemia was identified in 71 (60.7%) cases. Patients with anemia were diagnosed earlier than other patients (5.2±4.5 vs. 15.3±33.8 years, p=0.012). Among CD patients with anemia 39 (54.9%) were having iron deficiency, 22 (30.9%) were having folate deficiency and 10 (14%) were having vitamin B 12 deficiency. In patients with tissue transglutaminase (tTG) seropositivity serum iron levels and ferritin levels were significantly lower compared to anti-gliadin antibody (AGA) or anti-endomysium antibody (EMA) seropositivity (35±23.5 vs. 57.5±33.3, p=0.007 and 12.4±21.9 vs. 24.2±18.5, p=0.026, respectively). Low serum folate levels were more frequent in the presence of tTG seropositivity compared with AGA+EMA seropositivity (81.8% vs. 25%, p=0.015). Conclusions: Anemia is an important cause of admission in CD. These patients are diagnosed earlier as a result of anemia. Alone tTG seropositivity is more valuable to demonstrate anemia associated with iron or folate deficiencies.

Keywords: Celiac disease, serological tests, anemia, child
Effectiveness of balneotherapy in knee osteoarthritis

Effectiveness of balneotherapy in knee osteoarthritis

Authors: Bilal Uysal, Kagan Ozkuk
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Abstract

Aim: We aimed to investigate the effects of balneotherapy on knee osteoarthritis in present randomized controlled single blind clinical trial. Methods: Patients with knee osteoarthritis according to ACR criteria whom admitted to our institute were randomly assigned to two groups, 22 patients in each. Balneotherapy group received a total of 24 mixed thermo mineral baths at 37-38 ° C for 20 minutes in a schedule of 2 weeks, 6 days a week, 2 times a day in Gönen Spas. Patients in the control group were received medical treatment and monitored as outpatients. Study population were administered to pain (VAS), The Western Ontario and McMaster Universities Arthritis Index (WOMAC) and The Health Assessment Questionnaire (HAQ) evaluation before treatment, post treatment and on 4th week after treatment. In addition, 10 step ladder-up and 15 meter walking time was calculated. Results: Significant improvement in Pain (VAS), Pain (WOMAC-A), joint stiffness (WOMAC-B), joint function (WOMAC-C), The Health Assessment Questionnaire (HAQ) and in 10 steps ladder up and down tests achieved in balneotherapy group compared to pretreatment values. 15 meter walking time was improved at 4 week compared to baseline measurements. In control group, there was no significant improvement in the evaluated parameters at 4th week compared to pretreatment evaluation. Conclusion: We conclude that balneotherapy may be effective in improving pain and functional status in patients with knee osteoarthritis.

Keywords: Knee osteoarthritis, balneotherapy, Spa therapy
Mean Platelet Volume to Platelet ratio as a promising marker of hepatosteatosis

Mean Platelet Volume to Platelet ratio as a promising marker of hepatosteatosis

Authors: Mehmet Ali Kosekli, Edip Erkus, Mehmet Zahid Kocak
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Abstract

Aim: Hepatosteatosis confers increased lipid accumulation in the hepatocytes which is associated with inflammation. Hemogram parameters, such as mean platelet volume (MPV) and MPV to platelet ratio (MPR) are proposed as novel inflammatory markers in recent studies. We aimed to compare MPR of subjects with hepatosteatosis to those in healthy controls. Methods: Patient admissions to our clinic with a diagnosis of hepatosteatosis were retrospectively analyzed MPR values compared to those in healthy controls. Results: Mean MPR of hepatosteatosis group (0,04 ± 0,01fL/mm3) was significantly higher than the MPR of control subjects (0,03 ± 0,01 fL/mm3) (p=0.04). A Pearson’s Correlation analyze was revealed significant correlations between MPR and fasting plasma glucose (r=0.26, p=0.004) and between MPR and LDL-cholesterol (r=0.19, p=0.04). Conclusion: An elevated MPR should alert physicians for hepatosteatosis in otherwise healthy subjects. Therefore, calculation of MPR by automatic hemogram analyzers is advised.

Keywords: Mean platelet volume to platelet ratio, hepatosteatosis, inflammation
Mean Platelet volume to platelet and red cell distribution width to platelet ratios in Irritable Bowel Syndrome

Mean Platelet volume to platelet and red cell distribution width to platelet ratios in Irritable Bowel Syndrome

Authors: Burçin Meryem Atak, Edip Erkus, Tuba T. Duman, Mehmet Zahid Kocak, Mehmet Ali Kosekli
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Abstract

Aim: Irritable Bowel syndrome (IBS) is a common gastrointestinal disease worldwide with a broad spectrum of symptoms. In present retrospective study, we aimed to compare mean platelet volume to platelet ratio (MPR) and red cell distribution width to platelet ratio (RPR) values of IBS patients to those of healthy subjects. Methods: Patients whom followed up in internal medicine clinic of our institution between 2014 January to 2018 January were enrolled to the study. IBS subjects divided into constipation dominant or diarrhea dominant IBS groups. Healthy individuals visited our outpatient clinics for a check-up were enrolled as control group. Results: Median MPR of the constipation IBS, diarrhea IS and control groups were 0,034 (0,02-0,06), 0,034 (0,02-0,06), and 0,028 (0,01-0,05), respectively. The difference between groups was statistically significant (p=0.004). Conclusion: We think that elevated MPR in a patient with typical symptoms of IBS could be helpful in the diagnosis of the disease. Therefore, we suggest automatic calculation of MPR in hemogram assays.

Keywords: Irritable bowel syndrome, mean platelet volume to platelet ratio, inflammation, red cell distribution width to platelet ratio
Effects of the phosphodiesterase type-5 inhibitor tadalafil on nociception, morphine analgesia and tolerance in rats

Effects of the phosphodiesterase type-5 inhibitor tadalafil on nociception, morphine analgesia and tolerance in rats

Authors: Ahmet Sevki Taskiran, Ercan Ozdemir, Gokhan Arslan, Yasar Tastemur, Ahmet Kemal Filiz
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Abstract

Aim: Tadalafil is a potent, selective and reversible inhibitor of phosphodiesterase type 5 (PDE5) enzyme breakdowning cyclic guanosine monophosphate (cGMP). In this study, we aimed to investigate the effects of tadalafil on nociception, morphine analgesia and tolerance. Methods: In this study, 54 Wistar Albino (230-250 g) male rats were used. First of all, four different doses (2, 4, 8, 16 mg/kg) were used to determine the optimum effective dose of tadalafil on nociception. Optimum activity was found at 8 mg/kg and animals were divided into six groups: Saline (S), 8mg/kg tadalafil, 5mg/kg morphine (M), M+ tadalafil, morphine tolerance (MT) and MT+ tadalafil. Saline was given to the control group, tadalafil intraperitoneally and morphine subcutaneously administered at the indicated doses. To develop tolerance to morphine, 10mg/kg morphine was injected daily in the morning and evening for five days and tolerance was evaluated with single dose of morphine on sixth days. The resulting analgesic effect was measured with hot plate and tail flick analgesia tests and recorded at 30th, 60th, 90th and 120th minutes. Results: Tadalafil showed anti-nociceptive effect when given alone at different doses (p<0.05). However, tadalafil significantly decreased the analgesic effect of morphine (p<0.05). In addition, tadalafil significantly increased the tolerance to morphine (p<0.05). Conclusions: The phosphodiesterase type 5 inhibitor tadalafil have anti-nociceptive properties and it decreases analgesic effect of morphine, in addition improves tolerance development. These effects probably may occur via NO/cGMP pathway.

Keywords: Phosphodiesterase type 5 inhibitors, tadalafil, nociception, morphine analgesia, morphine tolerance
Can gestational exercise have a positive effect on cognitive functions resulting from brain injury? A rat study

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury? A rat study

Authors: Mustafa Dilek, Hayriye Orallar, Gokce Bozat, Nimet Kabakus, Ayhan Cetinkaya, Gamze Dilek, Fatma Karakas, Mustafa Erkocoglu, Ali Can Onal, Fahri Yilmaz
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Abstract

Aim: The effects of gestational exercise on potential pathological conditions is not known yet. Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on LPS-induced brain damage in pregnant rats. Method: Pregnant females in the experimental group were forced to exercise 30 min daily for five days a week. Lipopolysaccharide (LPS) induced brain injury model was created by administering 500 µg/kg body weight of LPS on gestational days 18 and 19. To evaluate injury histopathologically, brain tissues were fixed at the postnatal day seven through transcardial perfusion (n=4 pups/group). When the remaining pups reached 30-day of age, Morris water maze test (MWM) was performed to assess memory and learning, open filed (OP) and elevated plus maze (EPM) for testing anxiety, and Porsolt test (PT) for evaluating depression. The groups were defined as brain injury group (BI, n=13) and exercise+brain injury group (E+BI, n=7). Results: The results obtained from MWM test indicated that animals found the platform in a shorter duration and distance at the day five compared to the day three. However, there was no significant difference between the groups. No significant difference was found in OP test regarding the distance traveled, time spent at the margins, movement at the center and the time spent as immobile. However, in the EPM test, the offspring at the BI group displayed higher mobility and increased number of entry to the open arms compared to the E+BI groups (p=0.01). There was no significant difference regarding mobility duration and total distance traveled in the PT test. Conclusion: In the present study, we tested the impact of gestational exercise using the brain injury model. The results of the EPM test suggests that the gestational exercise can suppress the stress factors in the pregnant females with brain injury leading to the prevention of hyperactivity-induced negative learning behavior.

Keywords: Gestational exercise, cognitive functions, brain injury, neonatal, rat model, offspring
Obesity is associated with lower levels of Vitamin D

Obesity is associated with lower levels of Vitamin D

Authors: Edip Erkus, Aysen Helvaci, Mine Adas, Muge Bilge
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Abstract

Aim: In this study we aimed to compare the 25(OH) Vitamin-D level of obese patients and the serum 25(OH) Vitamin-D level of healthy individuals who have normal weight ;and also to evaluate the relation between 25(OH) Vitamin-D level and body mass index (BMI),waist circumference, hip circumference, body fat ratio. Methods: Among the patients who went into Okmeydani Training and Research Hospital Internal Medicine Polyclinic and the patients hospitalized at the Internal Medicine Clinic between the dates December 2012 - May 2013 and whose ages range between 18 and 70; total 105 individuals took part in the study. 62 individuals whose BMI is ≥30 formed the patient group, while 43 individuals whose BMI is between 18,5 and 25 formed control group. Vitamin-D level of the patient group and control group was measured. The data obtained was statistically analyzed. Results: The weight, BMI, waist circumference, hip circumference, body fat ratios of the patients in the case group were significantly higher than the ones in the control group (p<0.05). The 25 (OH) Vitamin-D level of the patients in the case group was significantly less than the ones in control group (p=0.03). There was statistically significant negative correlation between 25 (OH) Vitamin-D value and weight (r=-0.26 p=0.01), waist circumference (r=-0.23 p=0.02), and BMI (r=-0.26 p=0.01). Conclusion: Physicians should consider in treatment of vitamin-D deficiency that, serum vitamin-D levels are higher in obese compared to lean subjects and correlated negatively with BMI, weight and waist circumference.

Keywords: Obesity, 25(OH) Vitamin-D, waist circumference, body fat ratio, body mass index
Sequential vitamin D and parathyroid hormone measurement in patients with septic shock: Could they be prognostic marker in septic shock?

Sequential vitamin D and parathyroid hormone measurement in patients with septic shock: Could they be prognostic marker in septic shock?

Authors: Hasan Hacı Yeter, Oktay Halit Aktepe, Arzu Topeli
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Abstract

Aim: Hypocalcemia is a common clinical problem in critically-ill patients and it is associated with increased morbidity and mortality. The aim of this study was to investigate serum calcium, vitamin D and parathyroid hormone (PTH) levels in surviving and non-surviving septic shock patients Method: Patients with septic shock criteria and who were older than 18 years of age were included, whereas patients with diseases influencing calcium homeostasis were excluded. Demographic and laboratory parameters were recorded prospectively. Results: 41 patients, 20 of which were male were included in the study. The median (min-max) age of study population was 67 (19-88) years. Frequency of hypocalcemia in the study population was 29.2% and 68.2% according to corrected calcium and ionized calcium, respectively. On the day septic shock was diagnosed (day 1), median vitamin D levels of survivors and non-survivors were 8.7 ng/ml (4.3-30.4) and 5.3 ng/ml (1.0-21.7), respectively (p=0.05). On the same day, median PTH levels of survivors and non-survivors were 94 ng/L (16.9-1746) and 49 ng/L (6.6-339), respectively (p=0.042). Although vitamin D levels were suppressed and PTH levels were elevated in non-survivors at day 5, this change was not statistically significant (p=0.19 and p=0.187). Conclusion: Hypocalcemia is frequent in septic shock patients, whereas vitamin D levels were low and PTH levels were high in the diagnosis day. These results suggest that vitamin D is suppressed by septic shock at non-surviving patients during course of septic shock. Parathyroid hormone may be a marker for worse outcome in critically ill patients.

Keywords: Septic shock, parathyroid hormone, vitamin D, hypocalcemia, prognostic markers
Evaluation of retinal nerve fiber layer and ganglion cell layer thicknesses with optical coherence tomography in patients with vitamin B12 deficiency

Evaluation of retinal nerve fiber layer and ganglion cell layer thicknesses with optical coherence tomography in patients with vitamin B12 deficiency

Authors: Umit Dogan, Sule Aydın Turkoglu, Fatih Ulas, Adem Soydan, Abdulgani Kaymaz, Tarik Eroglu, Sumeyra Agca
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Abstract

Aim: We aimed to compare the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness of B12 vitamin deficiency patients with healthy controls using optical coherence tomography (OCT). Methods: Forty-six patients (27 females / 19 males) diagnosed with B12 vitamin deficiency and 46 healthy controls (26 females / 20 males) with similar age and sex were included in the study. RNFL thickness of global, superotemporal, temporal, inferotemporal, superonasal, nasal and inferonasal sectors and GCL thickness and volume measurements of central, superior, inferior, temporal, and nasal sectors were performed using Spectralis-OCT device in all cases. Results: The mean age of the patient group was 42.17±15.34 years, while that of the control group was 44.21±12.34 years (p=0.528). Mean serum vitamin B12 levels were measured as 163,47±19,80 pg/ml in the patient group and 311,80±76,30 pg/ml in the control group (p <0,01). There was no statistically significant difference between the global RNFL thicknesses of the two groups (p> 0,05). However, statistically non-significant thinning was observed in the superotemporal and global RNFL thickness of the group with B12 vitamin deficiency (p values are 0,140 and 0,171, respectively). There was also no statistically significant difference between GCL thicknesses and volumes of the two groups (p> 0.05). Conclusions: No significant reduction was observed in RNFL and GCL thicknesses of adult subjects with B12 vitamin deficiency compared with healthy controls.

Keywords: Ganglion cell layer, optical coherence tomography, retinal nerve fiber layer, vitamin B12 deficiency

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