A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding Journal title: The AAPS Journal Authors: Guohua An, Marilyn E. Morris Subject(s): Medicine
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation Journal title: The AAPS Journal Authors: Peng Zou, Yanke Yu, Nan Zheng, Yongsheng Yang, Hayley J. Paholak, Lawrence X. Yu, Duxin Sun Subject(s): Medicine
Challenges in Development of Nanoparticle-Based Therapeutics Journal title: The AAPS Journal Authors: Neil Desai Subject(s): Medicine
Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy Journal title: The AAPS Journal Authors: Narendra Chirmule, Vibha Jawa, Bernd Meibohm Subject(s): Medicine
Challenges and Opportunities in Achieving Bioequivalence for Fixed-Dose Combination Products Journal title: The AAPS Journal Authors: Amitava Mitra, Yunhui Wu Subject(s): Medicine
Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts Journal title: The AAPS Journal Authors: Lubna Abuqayyas, Joseph P. Balthasar Subject(s): Medicine
Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms Journal title: The AAPS Journal Authors: Stacey D. Finley, Aleksander S. Popel Subject(s): Medicine
Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats Journal title: The AAPS Journal Authors: Joost Westerhout, Bart Ploeger, Jean Smeets, Meindert Danhof, Elizabeth C. M. de Lange Subject(s): Medicine
Population Pharmacokinetics and Pharmacodynamics of Ribavirin in Patients with Chronic Hepatitis C Genotype 1 Infection Journal title: The AAPS Journal Authors: Runyan Jin, Michael J. Fossler, John G. McHutchison, Charles D. Howell, Thomas C. Dowling Subject(s): Medicine
Performance of Methods for Handling Missing Categorical Covariate Data in Population Pharmacokinetic Analyses Journal title: The AAPS Journal Authors: Ron J. Keizer, Anthe S. Zandvliet, Jos H. Beijnen, Jan H. M. Schellens, Alwin D. R. Huitema Subject(s): Medicine
Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics Journal title: The AAPS Journal Authors: Daniela Bumbaca, C. Andrew Boswell, Paul J. Fielder, Leslie A. Khawli Subject(s): Medicine
Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations Journal title: The AAPS Journal Authors: C. Andrew Boswell, Daniela Bumbaca, Paul J. Fielder, Leslie A. Khawli Subject(s): Medicine
Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry Journal title: The AAPS Journal Authors: Robert Erb, Katharina Leithner, Andreas Bernkop-Schnürch, Herbert Oberacher Subject(s): Medicine
Universal Immunoassay Applied During Early Development of Large Molecules to Understand Impact of Immunogenicity on Biotherapeutic Exposure Journal title: The AAPS Journal Authors: Ami C. Bautista, Hossein Salimi-Moosavi, Vibha Jawa Subject(s): Medicine
Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn Journal title: The AAPS Journal Authors: Yang Chen, Joseph P. Balthasar Subject(s): Medicine
