Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data Journal title: The AAPS Journal Authors: Thierry Wendling, Nikolaos Tsamandouras, Swati Dumitras, Etienne Pigeolet, Kayode Ogungbenro, Leon A... Subject(s): Medicine
A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to Humans Journal title: The AAPS Journal Authors: Youwei Bi, Jiexin Deng, Daryl J. Murry, Guohua An Subject(s): Medicine
Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds Journal title: The AAPS Journal Authors: Rui Li, Tristan S. Maurer, Kevin Sweeney, Hugh A. Barton Subject(s): Medicine
Pharmacometric Models for Characterizing the Pharmacokinetics of Orally Inhaled Drugs Journal title: The AAPS Journal Authors: Jens Markus Borghardt, Benjamin Weber, Alexander Staab, Charlotte Kloft Subject(s): Medicine
Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption Journal title: The AAPS Journal Authors: Andrés Olivares-Morales, Hans Lennernäs, Leon Aarons, Amin Rostami-Hodjegan Subject(s): Medicine
Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site Journal title: The AAPS Journal Authors: Helen Musther, Katherine L. Gill, Manoranjenni Chetty, Amin Rostami-Hodjegan, Malcolm Rowland, Masou... Subject(s): Medicine
Assessment of In Vivo Clinical Product Performance of a Weak Basic Drug by Integration of In Vitro Dissolution Tests and Physiologically Based Absorption Modeling Journal title: The AAPS Journal Authors: Xuan Ding, Ivelina Gueorguieva, James A. Wesley, Lee J. Burns, Carrie A. Coutant Subject(s): Medicine
Comparison of Deconvolution-Based and Absorption Modeling IVIVC for Extended Release Formulations of a BCS III Drug Development Candidate Journal title: The AAPS Journal Authors: Filippos Kesisoglou, Binfeng Xia, Nancy G. B. Agrawal Subject(s): Medicine
Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches Journal title: The AAPS Journal Authors: Hannah M. Jones, Kapil Mayawala, Patrick Poulin Subject(s): Medicine
A Simplified PBPK Modeling Approach for Prediction of Pharmacokinetics of Four Primarily Renally Excreted and CYP3A Metabolized Compounds During Pregnancy Journal title: The AAPS Journal Authors: Binfeng Xia, Tycho Heimbach, Rakesh Gollen, Charvi Nanavati, Handan He Subject(s): Medicine
Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin Journal title: The AAPS Journal Authors: Po-Chang Chiang, Harvey Wong Subject(s): Medicine
A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding Journal title: The AAPS Journal Authors: Guohua An, Marilyn E. Morris Subject(s): Medicine
Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats Journal title: The AAPS Journal Authors: Joost Westerhout, Bart Ploeger, Jean Smeets, Meindert Danhof, Elizabeth C. M. de Lange Subject(s): Medicine
The Pharmacokinetic/Pharmacodynamic Pipeline: Translating Anticancer Drug Pharmacology to the Clinic Journal title: The AAPS Journal Authors: Qingyu Zhou, James M. Gallo Subject(s): Medicine
Physiologically Based Pharmacokinetic Model of Amphotericin B Disposition in Rats Following Administration of Deoxycholate Formulation (Fungizone®): Pooled Analysis of Published Data Journal title: The AAPS Journal Authors: Leonid Kagan, Pavel Gershkovich, Kishor M. Wasan, Donald E. Mager Subject(s): Medicine
