Synthesis and Pharmacological Characterization of a Novel Sigma Receptor Ligand with Improved Metabolic Stability and Antagonistic Effects Against Methamphetamine Journal title: The AAPS Journal Authors: Michael J. Seminerio, Matthew J. Robson, Ahmed H. Abdelazeem, Christophe Mesangeau, Seshulatha Jamal... Subject(s): Medicine
Dopamine D2 Occupancy as a Biomarker for Antipsychotics: Quantifying the Relationship with Efficacy and Extrapyramidal Symptoms Journal title: The AAPS Journal Authors: Rik de Greef, Alan Maloney, Per Olsson-Gisleskog, Joep Schoemaker, John Panagides Subject(s): Medicine
Pharmacodynamic Model of Parathyroid Hormone Modulation by a Negative Allosteric Modulator of the Calcium-Sensing Receptor Journal title: The AAPS Journal Authors: Anson K. Abraham, Tristan S. Maurer, Amit S. Kalgutkar, Xiang Gao, Mei Li, David R. Healy, Donna N.... Subject(s): Medicine
Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents Journal title: The AAPS Journal Authors: Nidhi Kaushal, Matthew J. Robson, Harsha Vinnakota, Sanju Narayanan, Bonnie A. Avery, Christopher R.... Subject(s): Medicine
Quantitative PK–PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans Journal title: The AAPS Journal Authors: Cheng Chang, Wonkyung Byon, Yifeng Lu, Leslie K. Jacobsen, Lori L. Badura, Aarti Sawant-Basak, Emily... Subject(s): Medicine
Role of Cannabinoids in the Development of Fatty Liver (Steatosis) Journal title: The AAPS Journal Authors: Vishnudutt Purohit, Rao Rapaka, David Shurtleff Subject(s): Medicine
Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions Journal title: The AAPS Journal Authors: Louis S. Premkumar Subject(s): Medicine
Pharmacodynamics-Mediated Drug Disposition (PDMDD) and Precursor Pool Lifespan Model for Single Dose of Romiplostim in Healthy Subjects Journal title: The AAPS Journal Authors: Yow-Ming C. Wang, Wojciech Krzyzanski, Sameer Doshi, Jim J. Xiao, Juan Jose Pérez-Ruixo, And... Subject(s): Medicine
Targeting Fatty Acid Amide Hydrolase (FAAH) to Treat Pain and Inflammation Journal title: The AAPS Journal Authors: Joel E. Schlosburg, Steven G. Kinsey, Aron H. Lichtman Subject(s): Medicine
Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines Journal title: The AAPS Journal Authors: Thomas K. H. Chang Subject(s): Medicine
Partial derivative—Based sensitivity analysis of models describing target-mediated drug disposition Journal title: The AAPS Journal Authors: Anson K. Abraham, Wojciech Krzyzanski, Donald E. Mager Subject(s): Medicine
Receptors of mammalian trace amines Journal title: The AAPS Journal Authors: Anita H. Lewin Subject(s): Medicine
Targeting opioid receptor heterodimers: Strategies for screening and drug development Journal title: The AAPS Journal Authors: Achla Gupta, Fabien M. Décaillot, Lakshmi A. Devi Subject(s): Medicine
Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions Journal title: The AAPS Journal Authors: Basil O. Gerber, Werner J. Pichler Subject(s): Medicine
Anti-HIV Drug Development Through Computational Methods Journal title: The AAPS Journal Authors: Wan-Gang Gu, Xuan Zhang, Jun-Fa Yuan Subject(s): Medicine