LUBIPROSTONE: A NOVEL DRUG TO TREAT CONSTIPATION
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 2
Abstract
Lubiprostone, a bicyclic fatty acid, is a novel drug of new class of agents called prostones. It is approved by US FDA for the treatment of chronic constipation and constipation associated irritable bowel syndrome (IBS-C). It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit and improve symptoms of constipation. Lubiprostone is well tolerated in majority of the patients with nausea being the most common adverse effect. Lubiprostone represents a new approach of treatment in cases of resistant or intolerable cases of chronic constipation with proven efficacy and safety.
Authors and Affiliations
Kamlesh Garg*| Assistant Professor, Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi, Surinder Kumar| Medical officer, Department of Anesthesia, VMMC and Safdarjung Hospital, New Delhi, Ruchika Nanda| Assistant Professor, Department of Pharmacology, Dr HSJ Institute of Dental Sciences, Panjab University, Chandigarh, Suraj B| Junior Resident, Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi
Keywords
Related Articles
- EP ID EP1345
- DOI -
- Views 652
- Downloads 53
PREVALENCE OF AmpC β LACTAMASES IN NON-FERMENTING GRAM NEGATIVE BACILLI FROM CLINICAL ISOLATES.
Background and Objectives: Non fermenting gram negative bacilli (NFGNB) producing AmpC β lactamases an increasing cause of concern in the hospitals as they produce a therapeutic dilemma for the treating physician.The pre...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF TIZANIDINE HYDROCHLORIDE
The aim of this study was to formulate and evaluate the sustained release matrix tablet of Tizanidine hydrochloride. Tizanidine hydrochloride tablets were prepared by wet granulation technique using different polymers li...
Chemical composition of volatile extract of Gnaphaliumluteo-album l. Its and its antibacterial activity
The quantitative and qualitative analysis of the oil by GC and GC-MS, led to the identification of 14 constituents, constituting 96.13 % of the volatile extract.It was mainly characterized by the dominant presence of hyd...
Knowledge, attitude and practice of medicated contraception among females of reproductive age group
Lack of knowledge of contraception has lead to increased maternal mortality, morbidity due to unsafe abortion. Hence our study was aimed to determine knowledge, attitude and practice of contraception and impact of socio...
ETHOSOMES: A NOVEL APPROACH IN TRANSDERMAL DELIVERY OF THE DRUGS
Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corne...