1,1-Dichloroethene. Documentation
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2013, Vol 29, Issue 3
Abstract
1,1-Dichloroethene (vinylidene chloride) is a low temperature boiling liquid with a sweet scent. 1,1-Dichloroethene is used as a chemical intermediate (usually with vinyl chloride) in the production of thermoplastic resins, lacquers, fibres for safety clothes, etc. In hu-man, acute toxicity of 1,1-dichloroethene at concentration of ca. 16 000 mg/m[sup]3[/sup] was observed as a CNS depression (stunning and loss of consciousness). After acute inhalation or oral administration of 1,1-dichloroethene to laboratory animals some reversed adverse effects were observed in liver, kidneys and Clara cells. 1,1-Dichloroethene was mutagenic in Salmonella Typhimurium and Escherichia coli only due to metabolic activation. IARC concluded that there was inadequate evidence in humans and limited evidence in laboratory animals of the carcinogenicity of 1,1-dichloroethene. This substance is not classifiable as to its carcinogenicity to humans (IARC Group 3). Results of a 17-month inhalation study in rats exposed to 1,1-dichloroethene concentra-tion of 100 or 300 mg/m[sup]3[/sup] were considered in setting a maximum admissible concentration (MAC) value. Reversible fatty infiltration of the liver was reported in rats but no hematological alternations, no change in liver weight and no other indications of abnormal liver function were observed. Based on the LOAEC value for female rats (100 mg/m[sup]3[/sup]) and the relevant uncertainty factors, a MAC value of 8 mg/m[sup]3[/sup] has been calculated. No STEL nor BEI value has been established.
Authors and Affiliations
Danuta Ligocka, Agnieszka Jankowska, Sławomir Czerczak
Keywords
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