[(3-R-2-ОXO-2H-[1,2,4]TRIAZINO[2,3-С]QUINAZOLIN-6-YL)THIO]ACETAMIDES WITH THE FRAGMENTS OF CARCASE АMINES – EFFECTIVE SARS CORONAVIRUS INHIBITORS
Journal Title: Science Review - Year 2018, Vol 4, Issue 3
Abstract
It was shown, that N-cycloalkyl-(cycloalkaryl)-2-[(3-R-2-оxo-2Н-[1,2,4]triazino¬[2,3-с]quinazolin-6-yl)thio]acetamides revealed antiviral activity against SARS Coronavirus in visual test for V (inhibition of viral cytopathic effect) and NR (increase in NR dye uptake). Results for each tested compound were reported as virus-inhibitory concentration, 50 % endpoint (EC50 mg/ml), or 90 % effective concentration (EC90 mg/ml) and cell-inhibitory concentration, 50 % endpoint (CC50 mg/ml) were determined. The high inhibiting activity of compounds (ЕС50 1.0-33.0 mg/ml) was estimated. It was noted, that antiviral effect of compound 1.4 was comparable with test drug. It was shown, that planar [1,2,4]triazino[2,3-c]quinazoline system caused antiviral activity, additionally established by carcase аmines fragment and depend on the nature of substituent in 3rd position.
Authors and Affiliations
G. G. Berest
Keywords
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