6 THE HEMOSTATIC MECHANISMS IN PIH
Journal Title: Indian journal of applied basic medical sciences - Year 2015, Vol 17, Issue 24
Abstract
INTRODUCTION: Pregnancy induced hypertension (PIH) is a major complication of pregnancy and is one of the major causes of maternal mortality and perinatal complications. Changes in coagulation system in established preeclampsia are well documented. Out of all haematological changes that occur in preeclampsia, thrombocytopenia is the most common.2 the parameters studied in the present study support the aetiopathogenesis of clinical manifestations & help to reduce further fetal and maternal complications.AIMS & OBJECTIVE: To assess the association of bleeding time, Clotting time and Platelet count withPIH.MATERIALS AND METHODS: 30 diagnosed cases of preeclampsia blood pressure ˃ 140/90mmHg & proteinuria ˃300mg/l in 24hour after 20 weeks of gestation. 30 age, parity and gestation matched normotensive pregnant women subjects were taken for the study. Bleeding time, Clotting time and Platelet count were measured.Statistical analysis was done by using student‘t’ test between the two groups. A p-value less than 0.05 were considered as significant.RESULTS: Bleeding time and clotting time were prolonged in PIH but was not statistically significant. The platelet count is decreased in PIH which is statistically significantCONCLUSION: Prolonged bleeding time may be due to generalized vasoconstriction. Prolonged Clotting time was due to further depression of fibrinolytic activity. The lower platelet count in preeclampsia is associated with abnormal activation of coagulation system & is believed to reflect increased platelet consumption.
Authors and Affiliations
Dr. Veena H C, Manjunatha S
Keywords
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