A Case of X-Linked Agammaglobulinemia Presenting with Recurrent Pneumonia and Bronchiectasis
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2020, Vol 64, Issue 5
Abstract
Recurrent infection especially recurrent sinopulmonary tract infection is a typical clinical condition for referral to pediatrician. Patients with recurrent pneumonia should be evaluated for underlying diseases including asthma, congenital heart diseases, gastroesophageal reflux, foreign body aspiration, structure anomalies, cystic fibrosis and immunodeficiency. Our one patient with recurrent pneumonia had hypoglobulinemia, low number of circulating B cell with deficiency of CD19 B cell, absence of tonsils and recurrent pneumonia requiring hospitalization. PCR and sequencing revealed mutation of Bruton tyrosine kinase (Btk) gene on Xq22, suggested that he had X-linked agammaglobulinemia (XLA). The appropriate treatment of XLA was good hygiene care, treatment of infection and prophylactic therapy with intravenous immunoglobulin. This report should alert the pediatrician and general practitioners to consider the diagnosis of primary immunodeficiency diseases. The early diagnosis and proper management can prevent comorbidity diseases and improve quality of patient’s life.
Authors and Affiliations
Sirasuda Sommanus
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A Study of Self-Care Behaviors in Older Adults at the Elderly Club of Ratchaphiphat Hospital, on the Foundations of Personal and Social Support Factors
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The Incidence and Factors Related to the Retinopathy of Prematurity in a Tertiary Hospital in Bangkok, Thailand
OBJECTIVE: To address the incidence, treatment outcomes, and risk factors of retinopathy of prematurity (ROP). METHODS: The medical records were retrospectively reviewed of preterm infants who were examined for ROP at V...
A Case of X-Linked Agammaglobulinemia Presenting with Recurrent Pneumonia and Bronchiectasis
Recurrent infection especially recurrent sinopulmonary tract infection is a typical clinical condition for referral to pediatrician. Patients with recurrent pneumonia should be evaluated for underlying diseases including...
Risk Factors Associated with Birth Asphyxia of Neonate at Faculty of Medicine, Vajira Hospital
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