A Case Report of two Chronic Myeloid Leukemia Patients in Chronic Phase Exhibiting IgVH Gene Rearrangement
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 10
Abstract
In CML-CP, 90% of patients present with ph chromosome as sole genetic abnormality in neoplastic cells. Among the additional cytogenetic abnormalities, loss of Y chromosome, trisomy 8, trisomy 19, other single chromosome/gene abnormalities and complex abnormalities with double ACAs were found in that order. Abnormalities involving 14q32 has not been found in literature describing CML-CP, and in limited number of studies have been shown to be exclusively found in lymphoid blast crisis. We are presenting two cases of Chronic myeloid leukemia here, who presented to us with IgVH rearrangement along with ph+ chromosome, and are in chronic phase without any haematological or molecular indication of progressive disease.
Authors and Affiliations
Asif Iqbal
Keywords
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