A Clinical Study of Multiple Myeloma with Special Reference to Clinical Presentation in a Tertiary Care Hospital.
Journal Title: Journal of Medical and Dental Science Research (Quest Journals JMDSR) - Year 2018, Vol 5, Issue 2
Abstract
Multiple Myeloma (MM) is a clonal B-cell tumour of differentiated and usually slowly proliferating plasma cells. It accounts for about 1% of all malignant disorders. It has a strong correlation with age and the risk increases with age, peaking at about 60-70 years. In this study we have set out to determine the various signs and symptoms of the patients of multiple myeloma at the time of presentation. . A total of 52 patients were evaluated from April 2015 to April 2016 in the department of Clinical Haematology, Gauhati Medical College and Hospital. Patients were put on different treatment regimens as per the institutional protocol and followed up for a period of 4 months. As described in literature most of the patients presented with symptoms of bone pain, anaemia, infection and hyercalcaemia. This study also stages the patients according to the Revised International Staging System and assesses the short term outcome of different treatment regimens. A greater number of patients presented with advanced stage disease (stage III – 44.23%). Fluorescent in situ hybridization( FISH )studies were conducted in 19 patients of which 52.93% fall in the low risk group and 21.05% fall in the high risk group. Three drug regimen showed better outcome compared to two drug regimen with increased number of patients demonstrating Stringent complete response(sCR) and Complete response(CR).
Authors and Affiliations
Dr. Partha Pratim Kalita, Dr. Jina Bhattacharyya, Dr. Sangitanjan Dutta
Keywords
Related Articles
- EP ID EP578607
- DOI -
- Views 124
- Downloads 0
A Review on Endodontic Management in Traumatized Permanent Teeth
The majority of accidents affect children and adolescents, often when root development of the injured teeth is not completed. Teeth with immature root development, necrotic pulps, and apical periodontitis present multipl...
Relative Ratios of Methods Applied for Endodontic Treatment of Primary Teeth
Background: Endodontic therapy in cases of emergency aims to overcome pain and control inflammatory processes.It has been scientifically established that approximately 90% of the patients of child’s age, seeking for urge...
Periodontal Management Of Amlodipine-Induced gingival Over Growth: A 2 Years Follow-Up Case Report
Gingival overgrowth (GO) is one of the most important clinical features of gingival pathology. It has been found to be associated with the use of anticonvulsants; phenytoin, anti-hypertensives; calcium channel blockers a...
Effect of Chronic Consumption of Calabash Chalk Diet (Nzu) On Locomotor Activities in Swiss White Mice.
There are safety concerns as regards the consumption of Calabash chalk which is common practice in some localities in Africa and Asia. The effect of chronic Consumption of calabash chalk on locomotive activities in the S...
Internal Root Resorption “Sixty Four Thousand Dollar Questions to Dental Clinician ” : A Case Series Report
An endodontist has to encounter a multitude of pulpo-pathologic conditions. One such challenging condition is resorption. Management of internal root resorption is a challenge to the endodontists . It may occur in cases...