A Clinical Study of Multiple Myeloma with Special Reference to Clinical Presentation in a Tertiary Care Hospital.
Journal Title: Journal of Medical and Dental Science Research (Quest Journals JMDSR) - Year 2018, Vol 5, Issue 2
Abstract
Multiple Myeloma (MM) is a clonal B-cell tumour of differentiated and usually slowly proliferating plasma cells. It accounts for about 1% of all malignant disorders. It has a strong correlation with age and the risk increases with age, peaking at about 60-70 years. In this study we have set out to determine the various signs and symptoms of the patients of multiple myeloma at the time of presentation. . A total of 52 patients were evaluated from April 2015 to April 2016 in the department of Clinical Haematology, Gauhati Medical College and Hospital. Patients were put on different treatment regimens as per the institutional protocol and followed up for a period of 4 months. As described in literature most of the patients presented with symptoms of bone pain, anaemia, infection and hyercalcaemia. This study also stages the patients according to the Revised International Staging System and assesses the short term outcome of different treatment regimens. A greater number of patients presented with advanced stage disease (stage III – 44.23%). Fluorescent in situ hybridization( FISH )studies were conducted in 19 patients of which 52.93% fall in the low risk group and 21.05% fall in the high risk group. Three drug regimen showed better outcome compared to two drug regimen with increased number of patients demonstrating Stringent complete response(sCR) and Complete response(CR).
Authors and Affiliations
Dr. Partha Pratim Kalita, Dr. Jina Bhattacharyya, Dr. Sangitanjan Dutta
Keywords
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