A Clinical Study of Thyroid Function Tests in Dysfuctional Uterine Bleeding
Journal Title: Indian Journal of Obstetrics and Gynecology - Year 2017, Vol 5, Issue 3
Abstract
Dysfunctional uterine bleeding is abnormal uterine bleeding in the absence of any palpable pelvic pathology and the most common encountered condition in gynecology. Thyroid abnormalities have been suggested as an imporatant to affect the menstrual pattern and probable cause cause of that bleeding. The present study is a cross-sectional study of 150 women with abnormal uterine bleeding in the reproductive age group undertaken in Government Medical College and Hospital over a period of 1 year. It was done to ascertain the correlation between thyroid dysfunction and AUB. The history was elicited according to the proforma. Anthroprometric measurements were taken and a detailed examination was done. T3, T4 and TSH levels were evaluated in the fasting rate and the results interpreted. In this study among 81 patients with menorrhagia, 15 patients (18.52%) had clinical hypothyroidism and 7 patients (8.6%) had subclinical hypothyroidism. This correlates with study by Andrew weeks in 1987 of 650 women with menstrual disturbances at the Jessop hospital who have stated that hypothyroidism is a greatly under diagnosed cause of menorrhagia. Some patients have a normal serum TSH despite low T3 and T4. This is explained by a downward resetting of the threshold for TSH inhibition. TSH setpoint for a particular serum T3, T4 increases with age and is also altered by personal and familial character. TSH values tend to change more rapidly because the half life of TSH is much shorter. The incidence of thyroid dysfunction in the population with AUB is 26.5% according to our study and hence selective screening of this population would result in a higher yield. A major benefit of routine testing is the earlier detection of unsuspected overt thyrotoxicosis or subclinical hypothyroidism or hyperthyroidism. Most clinicians advocate treatment of women with elevated TSH levels in view of risk of hypothyroidism subsequently. The Body Mass Index showed a significant correlation (p<0.001) with thyroid dysfunction. Hypothyroidism was associated with obesity. The Study showed a significant correlation between thyroid profile (T3, T4 and TSH) and AUB (p=0.076). The study showed significant association of menorrhagia with hypothyroidism and hypomenorrhea, oligomenorrhea were associated with hyperthyroidism.
Authors and Affiliations
Nandkishor V. More
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- EP ID EP459794
- DOI 10.21088/ijog.2321.1636.5317.11
- Views 83
- Downloads 0
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