A comparative analysis of biochemical parameters in exudative and transudative pleural fluids using different criterias: a study in a tertiary care centre
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 4
Abstract
Background: Pleural effusion is a common clinical problem resulting from thoracic or systemic diseases. Several biochemical parameters, serological and cytological markers are used to classify the type of pleural effusion. The oldest classification is Light’s criteria which categorizes exudates by meeting one of these criteria: Pleural to serum protein ratio> 0.5, pleural to serum LDH ratio> 0.6 and isolated LDH > two third of normal upper limit of serum LDH. Others criteria are protein gradient and Serum effusion albumin gradient. Combination of clinical findings along with biochemical findings along with cytology helps in determining the etiology of pleural effusion. Materials and Methods: One hundred fifty samples of pleural fluid paired with serum were examined. Pleural fluids were also subjected to biochemical study to find out the level of protein, albumin, glucose, Adenosine deaminase levels, LDH, total and differential cell counts, Gram’s stain and Modified Ziehl-Neelsen stain. Serum samples were evaluated for protein, albumin and LDH levels. Results: Out of 250 samples, total of 71.2% samples were exudative and 28.8% were transudative. There were 184 males and 66 females. Tuberculosis (42.7%) followed by para-pneumonic effusion (22%) was commonest etiology seen in exudative pleural effusions. In transudates, chronic liver disease (10.8%) followed by chronic renal disease (8.4%) was the commonest etiologies encountered. Light’s criteria was nearly successful in classifying all exudates. All the inflammatory effusions were 100% classified by pleural LDH levels. All transudates are correctly classified by Serum effusion albumin gradient. Conclusions: Light’s criteria was most sensitive in identifying exudates but not specific in cases of transudates specially heart failure patients. Light’s criteria was 97.7% successful in classifying exudative pleural effusion. Combination of pleural LDH and pleural fluid to serum protein ratio was successful in classify all the exudates correctly.
Authors and Affiliations
Ranjan Agrawal, Miti Gupta, Nitesh Mohan, Biswajit Das, Rajat Agarwal
Keywords
Related Articles
- EP ID EP242904
- DOI -
- Views 104
- Downloads 0
Vitamin D Levels and bone mineral density in postmenopausal women
Introduction and Objectives: Osteoporosis characterized by low bone mass is a major health problem in post-menopausal women. Bone Mineral Density (BMD) represents the density or thickness of bones. Vitamin D plays an imp...
Serum ferritin as a biomarker in hematological conditions
Objective: This study is to evaluate significance of serum ferritin in differentiating between different hematological conditions. Methods: This is a prospective study conducted on children aged between 1 to 12 years att...
A comparative analysis of insulin resistance among tribal and non-tribal population with Type 2 Diabetes using estimated glucose disposal rate
Objectives: To compare the Insulin resistance among Type 2 Diabetics of the local tribal and nontribal population who are reporting to OPD of Midnapur Medical College and Hospital. Method: This was a Unicentric, cross se...
A Multi Marker Evaluation of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA), an inflammatory joint disease, is also associated with systemic effects. Patients with RA have an increased risk of morbidity and mortality that is mainly attributable to cardiovasc...
Relationship between sweat function determined by the sudoscan and parameters of the metabolic syndrome in people with type 2 diabetes
Objective The aim of this study was to investigate the relationship between the sweat function and parameters of the metabolic syndrome in type 2 diabetes patientsMaterials and Methods This was a crosssectional study whi...