A COMPARATIVE EVALUATION OF DIFFERENT MEMBRANES FOR THEIR DIFFUSION EFFICIENCY: AN IN VITRO STUDY
Journal Title: Pharma Science Monitor-An International Journal Pharmaceutical Sciences - Year 2010, Vol 1, Issue 2
Abstract
The present study was undertaken to determine the diffusion rate of a drug from a semisolid dosage form using different membranes and to explore a membrane and to find out the comparative membrane identical to human skin with respect to diffusion rate of the drug from the selected dosage form. In the present study, Franz cell was used to carry out the diffusion study through fuzzy rat skin, hairless mouse skin, egg membrane, cellophane membrane and human skin. Diffusion rate of the drug was determined in 7.4 pH phosphate buffer for twelve hours, maintaining temperature to 37+ 0.5°C. The drug retention in the was also determined at the end of the diffusion studies. The study concluded that the rate of drug diffusion through the fuzzy rat skin was identical to that of human skin. Minimum and maximum drug retention was occurred in cellophane and fuzzy rat skin membranes respectively.
Authors and Affiliations
Viral Shah* , Sanjay Raval , Sapna Peer , U. M. Upadhyay
Keywords
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