A comparative study between the efficacy of fentanyl with bupivacaine 0.5%, buprenorphine with bupivacaine 0.5% and midazolam with bupivacaine 0.5% in spinal anesthesia for lower abdominal surgeries
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 8, Issue 1
Abstract
Background and Objectives: The major feared consequences of surgery experienced by the patient is pain, both physically and psychically, thus Providing the effective analgesia in post surgical period to the patients becomes challenging in the speciality of anesthesia. Multidimensional analgesic approaches like parenteral analgesics or regional analgesia with spinal adjuvants like opioids, benzodiazepines and a2 agonists are commonly practiced. The main intention of this study is to compare the analgesic efficacy of Fentanyl (A), Buprenorphine (B), midazolam (C) with bupivacaine intrathecally in lower abdominal surgeries. Materials and Methods: A Seventy five American society of anaesthesiologist physical status I and II patients scheduled for various surgeries in lower abdomen were identified and randomised into three groups of twenty five patients each and studied. Group A, B and C received fentanyl, buprenorphine and midazolam with hyperbaric bupivacaine respectively. Patients involved in studies were studied for intraoperative hemodynamic changes, onset of sensory, motor blockade, total period of analgesia, and peri operative complications for twenty four hrs post surgery. Visual Analog Score (VAS) was recorded at the end of surgery and hourly up to 8 hours and the time for rescue dose of analgesia was noted. ANOVA, SPSS version 16 was used for analysis. Results: We have found that all the three drugs provided pain relief for various lower abdominal surgeries with hemodynamic stability. Duration of analgesia was significantly higher in buprenorphine than fentanyl and midazolam groups (44616.99 mins Vs 22519.37 mins and263 14.63 mins with ‘P’ value < 0.01). Conclusion: supplementing bupivacaine with buprenorphine 60 micrograms intrathecally provides effective significant pain relief for longer period of time than fentanyl and midazolam in peri operative period.
Authors and Affiliations
M Dhakshinamoorthy, V Anandaraj
Keywords
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- EP ID EP440490
- DOI 10.26611/1015812
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