A comparative study of efficacy and safety of tramadol in male versus female patients suffering from pain
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 1
Abstract
Background : Gender difference exists both in pharmacokinetics and pharmacodynamics of various drugs. So this study was designed to evaluate efficacy and safety of Tramadol in males versus female patients suffering from pain. Material and Methods : An open randomized parallel group study was conducted . 100 patients enrolled were 50 males and 50 females coming to Department of Orthopedics, in a tertiary care hospital. All patients were divided into four groups of 25 each. Tramadol was prescribed in two doses of 50mg or 100mg BD for 7 to 14 days depending on severity (based on Visual Analogue Scale) and then patients were monitored and adverse drug reactions were noted in males and females. The data was analyzed statistically using T- test for efficacy and descriptive stats for assessing the safety. Results : Efficacy was assessed by comparing difference in mean score and mean percentage change in mean score. Comparing males and females taking 50 mg tramadol percentage improvement was not statistically significant (p > 0.05). While comparing 50 mg and 100 mg percentage improvement in groups was statistically significant (p <0.05). Comparing groups males and females, percentage of adverse drug reaction in females was higher on each dose of tramadol. Percentage of adverse drug reaction in group taking 100mg was higher compared to group taking 50mg tramadol. Conclusion: There was no significant difference in efficacy of tramadol between males and females on same dose. Females experience more adverse drug reactions than males on same dose of tramadol and ADR increases with increase in dose.
Authors and Affiliations
Kiranpreet Kaur
Keywords
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- EP ID EP410721
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