A Comparative Study of Efficacy of Dapsone and Corticosteroids for the Treatment of Lichen Planus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 9
Abstract
Lichen Planus is defined as papulo-squamous disorder of unknown etiology characterised by itchy papules over the flexors of the body. Lichen planus presents as pruritic, polygonal, purplish, plane topped papules or plaques. Lichen planus (LP) has various morphological variants with lichen planus vulgaris being the commonest variant. Mucous membranes, nails and hair are also involved in Lichen Planus. The objective of our study is to compare the efficacy of Dapsone and Corticosteroids in the treatment of lichen planus. This is a single centre, randomized, comparative study which was conducted in year 2015. The study was done in 60 patients of lichen planus. Lichen planus was confirmed by clinical and histopathological examination. Two groups of 30 patients each were made. One group was given dapsone 100 mg daily & an antihistamine for 3 months and the second group was given oral corticosteroids 10 mg twice daily for 3 months. The follow up of patients was done at 2, 4, 6 & 12 weeks and observations were noted and analysed. It was observed that the results were equally better with oral dapsone than oral corticosteroids alone. These results suggest that dapsone may be a better treatment modality with respect to efficacy, safety and cost-effectiveness in treatment of lichen planus. Keywords: lichen planus, dapsone, corticosteroids, efficacy, papulo squamous, flexors
Authors and Affiliations
Dr. Vippan Goyal, Dr. Shivy Sharma, Dr. Taniya Mahey, Dr. Shammi Goyal
Keywords
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