A Comparative Study of Epidural Dexmedetomidine and Clonidine as Adjuvant to 0.2% Isobaric Ropivacaine for Post Operative Analgesia in Lower Limb Orthopaedic Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 8
Abstract
Background: Various adjuvants are being used with local anesthetics for prolongation of analgesia like opioids, but the onset and duration of analgesia is improved when a local anesthetic is combined with alpha2 adrenergic agonist. Though, the effects of clonidine on local anesthetics have been extensively studied, there are limited studies demonstrating the effects of epidural dexmedetomidine on local anesthetics. Aims and objectives: To compare the efficacy, onset and duration of postoperative analgesia and side effects of clonidine and dexmedetomidine when used epidurally as an adjuvant to ropivacaine in patients undergoing lower limb orthopedic surgeries. Settings and Design: This study was designed to compare the efficacy, onset and duration of postoperative analgesia and side effects of clonidine and dexmedetomidine when used epidurally as an adjuvant to ropivacaine in patients undergoing lower limb orthopedic surgeries. Methods and Material: Patients were randomized into two groups- group ropivacaine with dexmedetomidine (RD) received 20 ml of 0.2% ropivacaine with 1 g/kg dexmedetomidine epidurally and group ropivacaine with clonidine (RC) received 20 ml of 0.2% ropivacaine with 2 g/kg clonidine. Onset and duration of analgesia and Ramsay sedation score and hemodynamic parameters were monitored and side effects if any noted. Statistical analysis used: mean±standard deviation for quantitative continuous data and compared by unpaired t-test. Result: The onset of analgesia (RD-4.4±0.67min, RC-6.3±0.74min) and duration of analgesia (RD-665.16±29.8min, RC-462.16±29.8min) were found to be significantly better in dexmedetomidine group. Better sedation score was seen in dexmedetomidine group. Conclusion: Epidural dexmedetomidine (1mcg/kg) and clonidine (2mcg/kg) with ropivacaine 0.2% had good efficacy however the dexmedetomidine provided faster and prolonged duration of postoperative analgesia and good sedation compared to clonidine.
Authors and Affiliations
Chhaya M. Suryawanshi
Keywords
Related Articles
- EP ID EP536273
- DOI 10.21088/ijaa.2349.8471.5818.6
- Views 81
- Downloads 0
A Comparative Study of Oral Gabapentin and Oral Clonidine as Preemptive Analgesia under Spinal Anesthesia for Abdomino-Pelvic Surgeries
Aim: To assess the effect of oral Gabapentin and oral Clonidine used as Preemptive analgesia to attenuate postoperative pain in patients undergoing elective Abdomino-Pelvic surgeries under Spinal Anesthesia. Objective: T...
Intrathecal Midazolam for Post Operative Pain Relief in Lower Segment Caesarean Section
Background: Postoperative pain relief is one of the important component which needs to be managed in patients undergoing lower segment cesarean section. Midazolam is a drug which can be used for postoperative pain relief...
Comparative Evaluation of Nerve Stimulation and Ultrasound Guidance for Popliteal Block: A Randomized Double Blinded Study
Popliteal block is one of the rarely performed regional anaesthetic techniques because it requires great expertise in anatomical land marks and is often very technically challenging. Recent introduction of ultrasound te...
A Comparative Study between Oral Pregabalin 150mg and Gabapentin 300mg for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy
This study designed to test the hypothesis that the preoperative use of pregabalin will reduce th consumption of analgesics after laparoscopic cholecystectomy and to compare its efficacy and side effects with that of gab...
Comparison of Modified Mallampati Test and Upper Lip Bite Test in Prediction of Difficult Endotracheal Intubation: A Prospective Study
Introduction: Unanticipated difficult laryngoscopic tracheal intubation accounts for a significant proportion of adverse anaesthetic outcome in clinical practice. Hence, it is important to identify patients with difficul...