A Comparative Study Of Etomidate And Midazolam Induction In Patients Undergoing Coronary Artery Bypass Graft Surgery
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 4
Abstract
Background :To compare the effects of etomidate and midazolam induction on hemodynamic changes during laryngoscopy and intubation in patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery. Method and Material : A total of 70 patients with triple vessel coronary artery disease, aged between 30 to 60 years undergoing CABG surgery were included in this prospective, comparative and randomized study and divided into two groups; group E (Etomidate group, n=35, 0.3mg/kg) and group M (Midazolam group, n=35, 0.15mg/kg). Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central venous pressure (CVP), cardiac output (CO), cardiac index (CI) and systemic vascular resistance index (SVRI) were recorded at various time points starting from preinduction till 10 minutes after intubation. Statistical Analysis: The SPSS, version 20 for Windows statistical software package (SPSS inc., Chicago, Illinois, USA). Results were analyzed using student’s t-test and paired t-test. Results: In group M after induction HR increased (P <0.05); SBP and MAP decreased (P <0.05), while at 1 min after tracheal intubation the values of HR increased and SBP decreased (p <0.05). Whereas in group E, HR and SBP increased remarkably at 1 min after intubation (P < 0.001 and P <0.05, respectively). Both the groups showed no significant change in DBP, CO and CI before and after intubation. There was significant decrease in CVP in both the groups (P <0.001). Group M showed significant decrease in SVRI (P <0.001). Conclusion :In comparison with Etomidate, Midazolam used for the induction of anesthesia in CABG surgery was more effective in preventing the adverse cardiovascular response to laryngoscopy and intubation.
Authors and Affiliations
Bordi Pancholi, Reema Meena
Keywords
Related Articles
- EP ID EP40033
- DOI -
- Views 341
- Downloads 0
Evaluation of directly measured LDL-Cholesterol in Assessing the Cardiovascular Risk Defined by Total Cholesterol/HDL-Cholesterol Ratio
Introduction: Commonly, LDL-cholesterol levels are estimated indirectly by Friedewald equation and called as calculated LDL (cLDL). Assays for direct determination of LDL-C have come into vogue to overcome the limitatio...
Prevalence rate of Buccally Displaced Canine and Its Dentoskeletal 3-Dimesional relation in Indian Population
Objective: The aim of the study was to analyse the prevalence and distribution of buccally displaced canines (BDCs) in subjects scheduled for orthodontic treatment and to investigate the association between BDC and sagi...
CNS Vasculitis Following Hair Dye Poisoning- A Rare Case Report
Hair dye ingestion is one of the common causes of suicidal poisoning in young females. It contains mainly Paraphenylenediamine (PPD), which is very toxic, resulting in high mortality in the form of acute renal failure, m...
Hair Tourniquet Syndrome, A missed diagnosis: Review of Literature
Hair tourniquet syndrome is a rare yet potentially devastating entity in children. Hair-thread tourniquet syndrome involves fibres of hair or thread wrapped around an appendage (toe, finger, clitoris, penis etc.) produ...
Serum Thyroglobulin antibody (anti-Tg) and Thyroperoxidase antibody (anti-TPO) levels in School Children from goiter endemic sub-Himalayan Tarai region of Eastern Uttar Pradesh, India
The entire sub-Himalayan tarai (flat lands) region is in the classical goiter endemic belt of India. Siddharthnagar district in Eastern Uttar Pradesh is located in the foot-hills of the Himalayas and made up of tarai (...