A Comparative Study Of Etomidate And Midazolam Induction In Patients Undergoing Coronary Artery Bypass Graft Surgery
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 4
Abstract
Background :To compare the effects of etomidate and midazolam induction on hemodynamic changes during laryngoscopy and intubation in patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery. Method and Material : A total of 70 patients with triple vessel coronary artery disease, aged between 30 to 60 years undergoing CABG surgery were included in this prospective, comparative and randomized study and divided into two groups; group E (Etomidate group, n=35, 0.3mg/kg) and group M (Midazolam group, n=35, 0.15mg/kg). Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central venous pressure (CVP), cardiac output (CO), cardiac index (CI) and systemic vascular resistance index (SVRI) were recorded at various time points starting from preinduction till 10 minutes after intubation. Statistical Analysis: The SPSS, version 20 for Windows statistical software package (SPSS inc., Chicago, Illinois, USA). Results were analyzed using student’s t-test and paired t-test. Results: In group M after induction HR increased (P <0.05); SBP and MAP decreased (P <0.05), while at 1 min after tracheal intubation the values of HR increased and SBP decreased (p <0.05). Whereas in group E, HR and SBP increased remarkably at 1 min after intubation (P < 0.001 and P <0.05, respectively). Both the groups showed no significant change in DBP, CO and CI before and after intubation. There was significant decrease in CVP in both the groups (P <0.001). Group M showed significant decrease in SVRI (P <0.001). Conclusion :In comparison with Etomidate, Midazolam used for the induction of anesthesia in CABG surgery was more effective in preventing the adverse cardiovascular response to laryngoscopy and intubation.
Authors and Affiliations
Bordi Pancholi, Reema Meena
Keywords
Related Articles
- EP ID EP40033
- DOI -
- Views 346
- Downloads 0
Haematological Parameters in Female Breast Cancer Patients in South Western Nigeria
This is a cross sectional study of age and variations of Haematological parameters among female breast cancer patients and apparently healthy individuals in South western Nigeria.. Eighty eight breast cancer patients fr...
Dermatoglyphics: An Economical Tool for Prediction of Diabetes Mellitus
Diabetes Mellitus being one of the curse of human civilization is said to be genetically linked. Dermatoglyphics of the individual are also genetically determined and remains constant throughout the life. In the presen...
Malignant transformation in sebaceous cyst- A case report
Sebaceous cysts are among the most frequent skin lesions that are removed in an outpatient clinic. We encountered a case of malignant transformation in a long-standing sebaceous cyst of the scalp in 65 year old male. C...
The History of Sexually Transmitted Diseases
The current review traces the historical trajectory of diseases which were termed „venereal‟ in ancient and medieval history to the present day form „sexually transmitted‟. The mention of these diseases in medieval his...
Liver Enzymes for Assessment of Severity of Organophosphorus Poisoning
Introduction: Organophosphorus poisoning is the most common mode of poisoning in rural population of agrarian countries. In such resource limited settings proper allocation of the resources based on the need for observa...