A COMPREHENSIVE REVIEW ON ANTIMICROBIAL ACTIVITY OF 1,3,4-OXADIAZOLE DERIVATIVES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Heterocyclic compounds possess diverse biological properties that has lead to intense study and research of these compounds. One of these compounds is oxadiazole which has been found to exhibit various pharmacological activities. Oxadiazole is a five membered heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. It exists in four isomeric forms. Out of its four isomers 1, 3, 4-oxadizole exhibited a wide range of biological activities which includes antibacterial, antitubercular, anticonvulsant, hypoglycemic, antiallergic, enzyme inhibitor, vasodialatory, antifungal, cytotoxic, antiinflammatory, analgesic, hypolipidemic, anticancer, insecticidal, ulcerogenic activities etc. The 1,3,4-Oxadiazole have shown significant antimicrobial activity against a wide variety of microorganisms like fungi, Gram +ve strains such as Staphylococcus aureus, Bacillus subtilis and Bacillus lintus and Gram –ve strains such as Escherichia coli, Vibrio cholera and Pseudomonas aeruginosa. Oxadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades for biological, medical and agricultural reasons. A large number of drugs used clinically have oxadiazole ring as a structural building block. The capacity of 1, 3, 4-oxadiazole nucleus to undergo variety of chemical reactions including electrophillic substitution, nucleophilic substitution, thermal and photochemical which make it medicinal backbone on which a number of potential molecules can be constructed. Present review is flooded with reports of antimicrobial activity of 1,3,4-oxadiazole derivatives published in various journals.
Authors and Affiliations
Nupur Jaiswal, Arvind Singh, Deepika Singh, Tanveer Ahmad
Keywords
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