A DISCUSSION ON INDIAN INDIGENOUS LAL: ORLYSATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
To discuss the use of LAL by using a reagent called ORLYSATE (LAL) –made from the (blue blood) hemolymph of the Orissan Horse Shoe Crab. Process technology for ORLYSATE has been developed in India {by this author}. It has been standardized at 10−15 and at 10−12, which are picogram and nanogram sensitive, respectively {i.e., nano technology}. Endotoxin in pharmaceuticals could be assayed via agglutination in 1 hr and via chromogenic quantified route in 16 minutes. All orals, injectables and parentrals can be directly assayed. Residual endotoxin, contamination and status of sterilisation (LPS free) could similarly be assayed via elution, soak and sample method. Septicemia / Endotoximia can also be determined at clinical level. ORLYSATE can also be used to assay potable water, meat and other eatables. LAL / ORLYSATE is mandatorily required for determining quality control at production level apart from other uses an test kit for meningitis. By-products equally expensive e.g. Import substitution and Exportable Antibiotic, Glycoprotiens and Immunoglobulins.
Authors and Affiliations
Deepak Bhattacharya
Keywords
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