A histopathologic study of the transverse carpal ligament and flexor tenosynovium in patients with idiopathic carpal tunnel syndrome
Journal Title: Eklem Hastaliklari ve Cerrahisi - Year 2006, Vol 17, Issue 2
Abstract
Objectives: In order to establish the histologic etiology of idiopathic carpal tunnel syndrome (CTS), we investigated histologic changes in the transverse carpal ligament and flexor tenosynovium. Patients and methods: Biopsy specimens of the transverse carpal ligament and tenosynovium of the 3rd and 4th flexor digitorum superficialis tendons were taken from 39 consecutive patients (37 women, 2 men; mean age 51 years; range 42 to 63 years) who underwent surgery for idiopathic CTS, and from eight control patients (2 women, 6 men; mean age 47 years; range 39 to 55 years) who did not have any complaints or findings related to CTS and were operated on for distal radial intra-articular fractures. All the specimens were evaluated blindly by the same pathologist. Results: In the study group, 34 specimens of the transverse carpal ligament and 32 specimens of the flexor tenosynovium, and all specimens of the control group were eligible for pathologic evaluation. No pathologic findings were present in the transverse carpal ligament in seven specimens (20.6%) and three specimens (37.5%) in the study and control groups, respectively. The remaining specimens exhibited myxoid degeneration, inflammation, chondrocytic cells, edema, or lipomatosis. Flexor tenosynovium specimens of both groups exhibited at least two pathologic findings, the most common being reactive perivascular mononuclear inflammation. There were no signs of dense lymphocyte infiltration. The only significant difference was increased vascularity in the study group (78.1% vs 37.5%; p
Authors and Affiliations
Erdem Bagatur, Sergulen Dervisoglu, Mehmet Albayrak, Ahmet Dogan, Erhan Mumcuoglu, Gazi Zorer
Keywords
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- EP ID EP107465
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