A Novel Application of CuInS2/Zns Quantum Dot Nanoparticles: Dopamine Detection in Neuronal Synapses
Journal Title: The 2nd Annual Meeting of International Center for Neuroscience Research - Year 2021, Vol 2, Issue 1
Abstract
Brain research is the most expanding interdisciplinary research that needs the state of the art technologies to offer advances and opportunities in order to better understanding of human brain while overcoming the challenges relating to the nervous system. One of the key challenges in neuroscience researches and therapies, is elucidating the mechanisms by which the neurotransmitter release take place. The understanding of the fundamental mechanisms of neurotransmitter release and the development of methods to measure the amount of released neurotransmitter is crucial for insight into a better understanding of many aspects of neurotransmission including neural circuitry and treating the diseases related to such as Parkinson. Despite the enormous number of studies carried out to illuminate this function, efficient methods for momentary detection and visualizing these tiny neurochemicals have not been developed yet. Recent progresses in nanotechnology have opened up a new horizon of the more potential contributions of this field with neuroscience which have brought these two concepts together. advances in nanomaterials have launched a new class of fluorescent labels by conjugating quantum dots (QDs) with biomolecules. Cadmium-based QDs have been by far the most developed in bioimaging; however, their doubtful future owing to high toxicity has turned researchers᾽ attention to more recently ternary nontoxic compounds, CuInS2. In this research, a novel application of CuInS2 nanoparticles in neuroscience has been proposed. Accordingly, a newly developed synthesis method have been exploited by applying hydrothermal synthesis. The synthesized nanoparticles have the ability to properly functionalize with capping ligands to track dopamine which plays a major role in Parkinson. The structural and optical analysis confirmed that QDs are very appropriate for neurotransmitter detection in a small synaptic cleft.
Authors and Affiliations
Mahzad Mirzaei
Keywords
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