A novel therapy with zoledronic acid od bone metastasis in advanced prostate cancer reflecting molecular investigations
Journal Title: Współczesna Onkologia - Year 2006, Vol 10, Issue 1
Abstract
Prostate cancer continues to represent a major therapeutic challenge. There is still observed a large number of patients worldwide. This malignancy is mainly diagnosed in industrialized countries. Dietary factors, lifestyle – related factors, and androgens have long been recognized as contributors to the risk of prostate cancer. During the last 10 years, molecular studies have provided unexpected molecular events showing the prostate cancer tumorigenesis and progression. The modern therapy of prostate cancer relies on hormonal therapy. One step further for treatment of androgen-independent prostate cancer means chemotherapy based upon docetaxel, estramustine, and glucocorticoids. Bone metastases are frequent in prostate cancer. One of the drawbacks of long-term hormone therapy has been reported in recent studies as the changed bone metabolism. Long-term treatment of zoledronic acid is safe and gives substantial clinical benefits for men with metastatic hormone-refractory prostate cancer. The huge challenge still exists to seek novel agents which will offer better results in the course of the entity. Imatinib is a well-known agent blocking the function of protein kinases, and one of them is associated with PDGF (platelet-derived growth factor) receptor. The latter could become a target in the treatment of prostate cancer. Vitamin D and its metabolites may improve results of chemotherapy used to control prostate cancer.
Authors and Affiliations
Gabriel Wcisło, Sylwia Oborska, Lubomir Bodnar, Katarzyna Szarlej-Wcisło, Cezary Szczylik
Keywords
Related Articles
- EP ID EP83626
- DOI -
- Views 85
- Downloads 0
Reconstructive breast surgery, assessment of patient\'s satisfaction
Introduction: Breast reconstruction is an element of the complex treatment of breast cancer. A fundamental oncological contraindication is a confirmed generalisation of the disease, whereas resignation from the reconstru...
Role of microRNA w patogenezie, diagnostyce i terapii nowotworów
This article presents in brief some basic facts regarding biogenesis and physiological function of microRNAs, which are potent regulators of cell proliferation, differentiation, apoptosis, embryogenesis and organogenesis...
Przednia resekcja odbytnicy – wybrane aspekty jakości życia chorych
Rak jelita grubego jest narastającym problemem nie tylko onkologicznym, ale przede wszystkim zdrowotnym współczesnego społeczeństwa w Polsce i na świecie. Badania nad jakością życia w chorobach przewlekłych są cennym źró...
Treatment of bone metastases in breast cancer patients
Bone metastases are a major problem in the clinical management of patients with breast cancer. With prolongation of survival, the challenge is to improve the quality of the patient’s remaining life. The treatment of me...
Treatment of basal cell epithelioma which has been growing for many years - a case report
Basal cell carcinoma (Ca basocellulare, basal cell epithelioma, basalioma, rodent ulcer) is the most common skin cancer. Skin cancers develop in sun-exposed areas and are common in men after the age of 40. Basal cell ca...