A Possible Mechanism for the Propagation of Pathological Proteins in Parkinson’s Disease
Journal Title: Journal of Parkinson’s Disease and Alzheimer’s Disease - Year 2015, Vol 2, Issue 1
Abstract
Parkinson’s disease is a common neurodegenerative disorder which recently has come to be regarded as a prion-like foldopathy, the latter term implying that the intercellular trafficking of abnormally folded proteins transmits disease between cells and produces pathology in target cells through the induction of a mis-folded state in normal protein in those cells. In the case of Parkinson’s disease, the prion-like protein primarily involved is alpha-synuclein and inclusions of this protein called Lewy Bodies are commonly found in the substantia nigra of affected patients. Over recent years considerable evidence has been developed to show that a variety of extracellular signaling molecules called intracrines can act in the intracellular space of their cells of synthesis or in target cells after intercellular trafficking. Thus there is some commonality between intracrinephysiology and the pathophysiology of prion-like foldopathies such as Parkinson’s disease. Here these issues and a possible nexus between Parkinson’s disease and intracrine biology are discussed.
Authors and Affiliations
Richard N. Re
Keywords
Related Articles
- EP ID EP207467
- DOI 10.13188/2376-922X
- Views 137
- Downloads 0
Classification of Parkinson’s Disease Using Data Mining Techniques
Parkinson’s disease is a human disease caused by tolerant disorder of the nervous system that affects movement. It grows slowly, occasionally initiated with a scarcely visible tremor in just one hand. But while a tremor...
Sporadic Parkinsonism-Dementia Complex of Rhode Island with Unusually Abundant Glial TDP-43 Immunoreactivity
Background: Parkinson’s disease can overlap with other forms of neurodegeneration; however its co-occurrence with both frontotemporal lobar degeneration and motor neuron disease is distinctly rare although characteristic...
Medical Driving Assessment Outcomes in Seniors Using The KSCAr+Drive: An In-Office Screening Tool to Assist Clinicians in Determining Driving Safety and Who to Refer for Medical Driving Assessments
Objectives: The purpose of this study was to examine how the KSCAr might be utilized to help identify seniors with MCI/Dementia as safe vs. unsafe to drive, or for whom referral to a medical driving assessment was requir...
Critical Assessment of the Status of Biomarkers for Alzheimer’s disease
Objective: We undertook a critical analysis of the status of the progress in the development of biomarkers for the detection of Alzheimer’s disease (AD). Methods: Biomarker studies involving imaging, metabolomics, lipid...
Alzheimer’s Disease: AdultOnset of Inborn Error of Methionine Metabolism
The cause and treatment of Alzheimer’s Disease remains obscure. It could arise from adult onset of an inborn error of metabolism of the essential amino acid methionine expressed through an alternate biochemical pathway f...